Introduction and aim: Location of research was the Psychiatric Clinic at the Clinical Hospital Centre Split from 01/01/2015 to 30/09/2015. The aim of research in this paper is to determine the prevalence of comorbid conditions among patients who simultaneously suffer from alcohol abuse and depression as well as to determine the number of patients who suffered from depression which eventually developed to substance (alcohol) abuse (as a comorbid condition) or the number of patients suffering from alcohol abuse developing depression as a consequence of alcoholism (secondary depression). Primary outcome measures were to attempt to record the share of primary and secondary diagnoses in the operated group by using data on age and relation between the number of patients and gender, followed by the aim to see how additional comorbidities influence with primary diagnosis and repeated hospitalization. Examinees and methods: Examinees are patients with symptoms of depression and alcoholism occurring simultaneously and their medical history has been taken into consideration. The condition of patients has been diagnosed according to the International Classification of Diseases (ICD-10) and a standard psychiatric interview involving patient's personal and environmental circumstances was also conducted. In total, 36 patients were examined (26 men and 10 women). Organization of research included an analysis of medical history of patients treated during the period concerned by use discharging notes and their mental status also, on the basis of which are gathered data for this research paper: gender, age, other mental disorders (such as PTSD) and the parameter such as the number of hospitalizations. Results: The male: female ratio of patients was 2.6:1. When it comes to age structure, the majority of patients belong to the 51 - 60 age group. The average lifespan in the operated group regardless of gender is 54 and there is no statistically relevant difference in age between men and women. The frequency of male patients is more significant in the middle age groups. Twenty three male patients in total with a secondary comorbid condition, which makes 63.89% of the operated group. Out of the total number of examinees, ten men were diagnosed with PTSD, being a comorbid condition, along with depression and alcoholism. Total ratio of all examined comorbid disorders between genders is 4.75:1. Differences with regards to gender showed statistically irrelevant which indicates high prevalence of comorbidity regardless of gender. The number of hospitalizations has been recorded in two groups: 1 – 2 hospitalizations and repeated hospitalizations (>2). According to data, more than this 90% of patients in this operated group are hospitalized, male patients being more often readmissioned to the hospital than female. Conclusions: The research conducted in the Psychiatric Clinic at the Clinical Hospital Centre Split from 01/01/2015 to 30/09/2015 determined that 36 patients showed symptoms of depression and alcohol abuse simultaneously. Male patients significantly outnumber female patients in the operated group and have higher relative frequencies around middle-age group. Prevalence of male patients could be in relation to the prevalence of the primary alcoholics within the operated group. Therefore, depression is more likely to appear secondary to diagnosis in this operated group and the relative frequencies of female patients around young- and old-age group may correspond with that assumption. The average lifespan of the patients regardless of gender can be related both to the progression of alcohol abuse around middle-age and depression around young- and old-age group, respectively. Most patients in the operated group are exposed to a comorbid condition which may indicate the co-occurence of primary diagnosis with a comorbid condition. This is especially the case for males, many of which suffer from PTSD. A majority of the male patients who undergo recurrent admissions could be in relation with higher rate of male comorbidity inside the operating group. Medical history of the patients does not provide data on the exact number and ratio of alcohol abuse as a comorbid depression inside the operating group and it is neither possible to determine which of the two psychiatric disorders is a primary diagnose due to statistical analysis. So general assumption has been brought which covers state group consisting of patients with a diagnosed condition of depression and alcoholism in a given period of this study.