| Abstract | Cilj istraživanja: Usporediti plazmatske koncentracije inaktivnog matriks Gla proteina (dp-ucMGP) u bolesnika s opstrukcijskom apnejom tijekom spavanja (OSA) i kontrolnoj skupini.
Ispitanici i metode: Ovo istraživanje je obuhvatilo ukupno 60 odraslih ispitanika, uključujući 30 ispitanika s opstrukcijskom apnejom tijekom spavanja (OSA) i 30 zdravih muških kontrolnih ispitanika. Dijagnoza OSA-e postavljena je polisomnografskim ispitivanjem u Centru za medicinu spavanja Medicinskog fakulteta u Splitu i KBC-a Split u razdoblju od listopada do prosinca 2017. godine, vodeći se preporukama AASM-a (engl. American Academy of Sleep Medicine, AASM) i ESRS-a (engl. European Sleep Research Society, ESRS). Svi ispitanici su podvrgnuti antropometrijskim mjerenjima i laboratorijskoj analizi krvi uz mjerenje plazmatske koncentracije inaktivnog MGP-a i hsCRP-a.
Rezultati: Ispitivane skupine nisu se statistički značajne razlikovale u antropometrijskim obilježjima osim u vrijednostima opsega vrata koje su bile značajno veće u OSA ispitanika (38,3±3,1 naspram 40,1±2,7 cm, P<0,001). Nadalje, plazmatske koncentracije inaktivnog MGP-a i hsCRP-a bile su značajno veće u OSA ispitanika u odnosu na kontrolnu skupinu (525,73±86,83 vs. 474,33±47,05 pmol/L, P=0,006 odnosno 3,31±1,39 vs. 1,42±0,79 mg/L, P<0,001). U OSA skupini je utvrđena statistički značajna pozitivna korelacija između inaktivnog MGP-a i apneja-hipopneja indeksa (r=0,489, P=0,006) te desaturacijskog indeksa (r=0,466, P=0,009). U ukupnom uzroku ispitanika je pronađena značajna pozitivna korelacija između inaktivnog MGP-a i hsCRP-a (r=0,463 P<0,001) te opsega vrata (r=0,454, P<0,001).
Zaključci: Plazmatske koncentracije inaktivnog MGP-a i hsCRP-a su značajno veće u OSA ispitanika u usporedbi s kontrolnom skupinom. Potrebna su daljnja istraživanja kako bi se učvrstile spoznaje o ulozi dp-ucMGP-a u patofiziologiji OSA-e, kao i utvrdila moguća stvarna klinička primjena navedenih spoznaja u skrbi pacijenata s OSA-om. |
| Abstract (english) | Objectives: The aim of this study was to compare the plasma concentrations of dp-ucMGP in obstructive sleep apnea (OSA) patients and healthy male individuals.
Materials and methods: This study included a total of 60 adult subjects, including 30 subjects with obstructive sleep apnea (OSA) and 30 healthy male control subjects. The diagnosis of OSA was made by polysomnographic examination at the Center for Sleep Medicine of the University of Split School of Medicine and University Hospital of Split in the period from October to December 2017, following the recommendations of the AASM (American Academy of Sleep Medicine, AASM) and ESRS (European Sleep Research Society, ESRS). All subjects underwent anthropometric measurements and laboratory blood analysis with measurement of plasma concentration of inactive MGP and hsCRP.
Results: The study groups did not differ significantly in anthropometric characteristics except in the values of neck circumference, which were significantly higher in OSA subjects (38.3±3.1 vs. 40.1±2.7 cm, P <0.001). Furthermore, plasma concentrations of inactive MGP and hsCRP were significantly higher in OSA subjects compared to the control group (525.73±86.83 vs. 474.33±47.05 pmol/L, P=0.006 and 3.31±1.39 vs. 1.42±0.79 mg/L, P<0.001, respectively). In the OSA group, a statistically significant positive correlation was found between inactive MGP and apnea-hypopnea index (r=0.489, P=0.006) and desaturation index (r=0.466, P=0.009). In the total cohort, a significant positive correlation was found between inactive MGP and hsCRP (r=0.463 P<0.001) and neck circumference (r=0.454, P<0.001).
Conclusions: Plasma concentrations of inactive MGP and hsCRP were significantly higher in OSA subjects compared to the control group. Further studies are necessary to strengthen the findings about the role of dp-ucMGP in the pathophysiology of OSA, and also to determine possible clinical uses of said findings in the treatment of OSA patients. |
