| Abstract | Cilj istraživanja: Cilj ovog istraživanja bio je ispitati razlike denzitometrijskih parametara i TBS indeksa između OSA i kontrolne skupine ispitanika te procijeniti 10-godišnji rizik za nastanak patoloških prijeloma u navedenim skupinama.
Ispitanici i postupci: Istraživanje uključuje 30 odraslih OSA bolesnika te 30 kontrolnih ispitanika usklađenih po dobi i antropometrijskim mjerama s ispitivanom skupinom. Svim ispitanicima uzeta je detaljna anamneza, kao i informacije o dnevnim navikama. Također su bili podvrgnuti denzitometrijskom snimanju i procjeni TBS indeksa, te se za svakog uključenog ispitanika računao 10-godišnji rizik od prijeloma putem FRAX® kalkulatora.
Rezultati: Nisu pronađene statistički značajne razlike u denzitometrijskim rezultatima između ispitivanih skupina. Međutim, vrijednosti TBS-a bile su značajno niže u OSA skupini u odnosu na kontrolnu skupinu ispitanika (1,20 ± 0,19 vs. 1,39 ± 0,12; P<0,001) te su negativno korelirale s AHI indeksom u oboljelih od OSA-e (r= -0,611; P<0,001). Isto tako, teška OSA skupina je imala značajno niži TBS u odnosu na umjerenu OSA skupinu (1,33 ± 0,15 vs. 1,15 ± 0,18; P=0,022). Značajnih razlika u procjenama 10-godišnjeg rizika od ozbiljnog prijeloma u FRAX® izračunima bez prilagodbe za TBS između OSA i kontrolne skupine nije bilo. Ipak, rizik prilagođen s TBS-om je bio značajno veći u kategorijama ozbiljnog prijeloma (2,85 (1,3-6,1) vs. 0,65 (0,3-1,1) %; P<0,001) i prijeloma kuka (0,1 (0,0-0,2) vs. 0,0 (0,0-0,1) %; P=0,007) u OSA skupini ispitanika u odnosu na kontrolne ispitanike. Nadalje, kod OSA skupine ispitanika, nije pronađena značajna povezanost AHI indeksa i 10-godišnjeg rizika izračunatog uobičajenim FRAX® alatom (r=-0,064; P=0,736), dok je kod FRAX®-a prilagođenog TBS-om vidljiva značajna pozitivna korelacija s AHI indeksom (r=0,444; P=0,014).
Zaključci: Ovo istraživanje je pokazalo da OSA bolesnici imaju značajno niže vrijednosti TBS indeksa u odnosu na kontrolnu skupinu, koje negativno koreliraju s AHI indeksom. Također, značajnih razlika u FRAX® izračunima bez uključivanja TBS-a između ispitivanih skupina nije bilo, dok su u FRAX® izračunima prilagođenim TBS-om OSA ispitanici imali značajno veći rizik od prijeloma u odnosu na kontrolnu skupinu. |
| Abstract (english) | Objectives: The aim of this study was to examine differences in densitometric parameters and trabecular bone score (TBS) between OSA patients and control group and to evaluate the 10 year probability of fractures in these groups.
Subjects and Methods: The study included 30 adult patients with OSA and 30 control subjects matched in age and anthropometric measures with the study group. All subjects underwent detailed anamnesis and daily habits questioning. They were also subjected to densitometric imaging and TBS calculation, and for each subject the 10-year probability of fracture was calculated using the FRAX® tool.
Results: No statistically significant differences in densitometric results were found between the examined groups. However, TBS scores were significantly lower in the OSA group compared to control group (1.20 ± 0.19 vs. 1.39 ± 0.12; P <0.001) and they were negatively correlated with AHI index in OSA patients (r = -0.611; P <0.001). Likewise, patients with severe OSA had significantly lower TBS compared to those with moderate OSA (1.33 ± 0.15 vs. 1.15 ± 0.18; P = 0.022). There were no significant differences in the evaluations of the 10 year probability of fracture using FRAX® tool without TBS adjustment between the OSA and the control group. However, the fracture risk in calculations adjusted with TBS was significantly higher in the categories of major osteoporotic fractures (2.85 (1.3-6.1) vs. 0.65 (0.3-1.1)%; P <0.001) and hip fractures (0.1 (0.0-0.2) vs. 0.0 (0.0-0.1)%; P = 0.007) in OSA patients compared to control subjects. Furthermore, in the OSA group, no significant correlation was found between AHI index and the 10-year fracture risk calculated by the usual FRAX® tool (r = -0.064; P = 0.736), while the FRAX® adjusted with TBS showed significant positive correlation with AHI index (r = 0.444; P = 0.014).
Conclusions: This study showed that OSA patients had significantly lower TBS scores compared to control group, which negatively correlated with AHI index. Also, there were no significant differences in FRAX® calculations without TBS between the study groups, while in FRAX® calculations adjusted with TBS, OSA subjects had a significantly higher risk of fracture compared to control group. |
