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master's thesis
Methodological tools and sensitivity analysis for assessing quality or risk of bias used in systematic reviews published in the high-impact anesthesiology journals
Split: University of Split, School of Medicine, 2020. urn:nbn:hr:171:809821
Marušić, Marija Franka
University of Split
School of Medicine
Research in biomedicine and health

Institutional repository: MEFST Repository

Cite this document

Marušić, M. F. (2020). Methodological tools and sensitivity analysis for assessing quality or risk of bias used in systematic reviews published in the high-impact anesthesiology journals (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:809821

Marušić, Marija Franka. "Methodological tools and sensitivity analysis for assessing quality or risk of bias used in systematic reviews published in the high-impact anesthesiology journals." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:809821

Marušić, Marija Franka. "Methodological tools and sensitivity analysis for assessing quality or risk of bias used in systematic reviews published in the high-impact anesthesiology journals." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:809821

Marušić, M. F. (2020). 'Methodological tools and sensitivity analysis for assessing quality or risk of bias used in systematic reviews published in the high-impact anesthesiology journals', Master's thesis, University of Split, School of Medicine, accessed 13 January 2025, https://urn.nsk.hr/urn:nbn:hr:171:809821

Marušić MF. Methodological tools and sensitivity analysis for assessing quality or risk of bias used in systematic reviews published in the high-impact anesthesiology journals [Master's thesis]. Split: University of Split, School of Medicine; 2020 [cited 2025 January 13] Available at: https://urn.nsk.hr/urn:nbn:hr:171:809821

M. F. Marušić, "Methodological tools and sensitivity analysis for assessing quality or risk of bias used in systematic reviews published in the high-impact anesthesiology journals", Master's thesis, University of Split, School of Medicine, Split, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:171:809821

Metadata
TitleMethodological tools and sensitivity analysis for assessing quality or risk of bias used in systematic reviews published in the high-impact anesthesiology journals
Title (croatian)Metodološki alati i analiza osjetljivosti za procjenu kvalitete ili rizika od pristranosti korišteni u sustavnim pregledima objavljenim u anesteziološkim časopisima visokog odjeka
AuthorMarija Franka Marušić
MentorLivia Puljak (mentor)
Committee memberDamir Sapunar (predsjednik povjerenstva)
Committee memberJoško Božić (član povjerenstva)
Committee memberShelly Pranić (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Research in biomedicine and health)
Split
Defense date and country2020-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Abstract
Objectives: A crucial element in the systematic review (SR) methodology is the appraisal of included primary studies, using tools for assessment of methodological quality or risk of bias (RoB). SR authors can conduct sensitivity analyses to explore whether their results are sensitive to exclusion of low quality studies or a high RoB. However, it is unknown which tools do SR authors use for assessing quality/RoB, and how they set threshold for quality/RoB in sensitivity analyses. The aim of this study was to assess quality/RoB assessment tools, the types of sensitivity analyses and quality/RoB thresholds for sensitivity analyses used within SRs published in high-impact pain/anesthesiology journals. Materials and methods: This was a methodological study. We analyzed SRs published from January 2005 to June 2018 in the 25% highest-ranking journals within the Journal Citation Reports (JCR) "Anesthesiology" category. We retrieved the SRs from PubMed. Two authors independently screened records, full texts, and extracted data on quality/RoB tools and sensitivity analyses. We extracted data about quality/RoB tools, types of sensitivity analyses and the thresholds for quality/RoB used in them. Results: Out of 678 analyzed SRs, 513 (76%) reported the use of quality/RoB assessments. The most commonly reported tools for assessing quality/RoB in the studies were the Cochrane tool for risk of bias assessment (N=251; 37%) and Jadad scale (N=99; 15%). Meta-analysis was conducted in 451 (66%) of SRs and sensitivity analysis in 219/451 (49%). Most commonly, sensitivity analysis was conducted to explore the influence of study quality/RoB (90/219; 41%) on the results. Quality/RoB thresholds used for sensitivity analysis for those studies were clearly reported in 47 (52%) articles that used them. The quality/RoB thresholds used for sensitivity analyses were highly heterogeneous and inconsistent, even when the same tool was used. Conclusions: A quarter of SRs reported using quality/RoB assessments, and some that did cited tools that are not meant for assessing quality/RoB. Authors who use quality/RoB to explore the robustness of their results in meta-analyses use highly heterogeneous quality/RoB thresholds in sensitivity analyses. Better methodological consistency for quality/RoB sensitivity analyses is needed.
Abstract (croatian)
Ciljevi: Procjena primarnih istraživanja koristeći alate za procjenu metodološke kvalitete ili rizika od pristranosti (RP) ključan je element u metodologiji sustavnih pregleda. Autori sustavnih pregleda mogu provesti analize osjetljivosti kako bi istražili jesu li im rezultati osjetljivi na isključivanje studija niže kvalitete ili onih s visokim RP. Međutim, nije poznato koje alate autori sustavnih pregleda koriste za procjenu kvalitete ili RP, te kako postavljaju prag kvalitete ili RP pri analizama osjetljivosti. Cilj ovoga istraživanja bio je ispitati vrstu alata za procjenu kvalitete ili RP, analize osjetljivosti i pragove za kvalitetu ili RP koji se koriste u sustavnim pregledima u časopisima iz područja anesteziologije i boli visokog odjeka. Materijali i metode: Ovo je bilo metodološko istraživanje. Analizirali smo sustavne preglede objavljene od siječnja 2005. do lipnja 2018. u časopisima koji se nalaze u prvih 25% rangiranih u kategoriji "Anesteziologija" baze Journal Citation Reports (JCR). Sustavne preglede smo prikupili s PubMed-a. Dvoje autora je nezavisno analiziralo zapise dobivene pretraživanjem, cjelovite tekstove i izvadilo podatke o upotrijebljenim alatima za kvalitetu ili RP i analizama osjetljivosti. Izvadili smo podatke o upotrijebljenim alatima za kvalitetu ili RP, vrstama analiza osjetljivosti i pragovima za kvalitetu ili RP. Rezultati: Od 678 analiziranih sustavnih pregleda, 513 (76%) je navelo uporabu procjene kvalitete/rizika od pristranosti. Cochraneov alat za procjenu RP (N=251; 37%) i ljestvica Jadad (N=99; 15%) bili su najčešće navedeni alati za procjenu kvalitete ili RP. Meta-analiza je izvedena u 451 (66%) sustavnom pregledu, a analiza osjetljivosti u 219/451 (49%). Najčešći razlog za provođenje analize osjetljivosti bilo je istraživanje utjecaja kvalitete studije ili RP (90/219; 41%) na rezultate. Pragovi kvalitete ili RP korišteni u analizama osjetljivosti tih istraživanja bili su jasno navedeni u 47 (52%) istraživanja koja su analizu provodila. Pragovi za kvalitetu ili RP korišteni u analizama osjetljivosti bili su vrlo heterogeni i nedosljedni, čak i kada se radilo o uporabi iste vrste alata. Zaključci: Četvrtina sustavnih pregleda navela je uporabu procjena kvalitete ili RP, a neki koji jesu, citirali su alate koji nisu namijenjeni za procjenu kvalitete ili RP. Autori koji koriste alate za procjenu kvalitete ili RP kako bi istražili snagu svojih rezultata u meta-analizama koriste vrlo heterogene pragove kvalitete ili RP u svojim analizama osjetljivosti. Nužna je metodološka dosljednost kod analiza osjetljivosti kvalitete ili RP.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:809821
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-11-16 10:52:30