Infertility is diagnosed in the case of pregnancy absence despite continuous unprotected sex for at least a year. As many as 15 % of the reproductive age population struggle with this problem. Infertility usually has its background and causes that led to such a condition, but as many as 15 % cases have an idiopathic background. This means that no causal factor was found. Smoking, alcohol, nicotine and caffeine also contribute to the diagnosis. Overweight is also a big problem, which also records an increase of incidence all around the world. Treatment begins with a detailed health history of both partners with all the necessary examinations (blood, urine, hormones, etc.). The woman will have a gynecological examination that will give insight into the condition and physiognomy of genitals. Man will have to do spermiogram test. By collecting the outcome of all these test, as well as some others, the most favorable method will be selected. No matter which method is chosen, the procedure is complex and mentally and physically exhausting. When all these are added to the fear of failure, stress and other daily obligations, it is clear that the couple is going through one od the most turbulent period in their lives. MPO include these methods : insemination, in vitro fertilization, intracytoplasmic injection and gamete/zygote transfer to the fallopian tube. With a complete team of human reproduction working together with the same goal - achieving pregnancy, a midwife has a big impact. It's exactly her who will meet the couple most usually. It's important that midwife shows understanding, give a words of comfort and simply be with them. That leads to creating a trust which has big importance in the process. The fight against infertility and entering into process are the most intimate parts of a human, so everybody needs to have an understanding, especially the medical team.