Diagnostic of chromosomopathies is an important part of prenatal care for pregnant women. The most commonly performed method of antenatal diagnosis of fetal chromosomal abnormalities is amniocentesis, more precisely early amniocentesis with the aim of fetal karyotyping. By analyzing the entire examined period, most early amniocentesis were performed between the 16th and 20th weeks of pregnancy. The introduction of the combined test and later non-invasive prenatal testing moved the average gestation age for performing early amniocentesis for one week: from the dominantly completed 17 weeks to 16. The most common indication for performing early amniocentesis in the studied population is the age of the pregnant woman. The observed reduction in the proportion of early amniocentesis due to family and personal history with a significant decrease in recent years is a sign of good clinical practice and developed internal procedures for indicating methods of invasive prenatal diagnostics. With the advent of non-invasive prenatal testing, the number of early amniocentesis in the Clinic has significantly decreased and the share of pathological karyogram findings has increased.