Infective endocarditis remains a rare condition, but one with high associated morbidity and mortality. With the aging of the population and the increasing use of implantable cardiac devices and heart valves, the epidemiology of infective endocarditis has changed. Early clinical suspicion and rapid diagnosis are crucial to enable access to the correct treatment pathways and reduce the rate of complications and mortality. The clinical presentation of infective endocarditis is highly variable and may present as an acute, subacute, or chronic condition that reflects changing causative microorganisms, underlying cardiac conditions, and preexisting comorbidities. In most patients, it is present with fever, night sweats, fatigue, and loss of weight and appetite. The diagnosis of infective endocarditis in cardiac surgical patients should be carefully considered in those with predisposing risk factors, heart murmurs, vasculitis and embolic events associated with infective endocarditis Antimicrobial therapy should generally not be initiated until three sets of blood cultures have been obtained. Aspects of nursing care are related to good assessment, detailed nursing anamnesis and timely response to all pathological changes after cardiac surgery. By creating a health care plan, the nurse prevents possible unwanted events that may threaten the patient's life and ensures the patient's recovery