The aim of this study is to compare the level of nicotine addiction in patients suffering from schizophrenia with regard to the acute phase of the disease and stable remission. The research was conducted in the period from March to May 2023 at the Clinical Hospital Center Split. A total of 60 respondents participated, of which 30 were in the acute phase of the disease, and 30 in the stable remission phase. The subjects are patients of the Department of Psychiatry, University Hospital Center Split who are treated stationary and outpatiently for schizophrenia. The study used a nicotine addiction test (fagerstrom). The questionnaire consisted of 6 questions. The research confirmed the hypothesis that respondents in the acute phase of the disease have a higher level of nicotine addiction compared to respondents in the stable remission phase. The hypothesis was confirmed that subjects who are in remission have a lower level of nicotine addiction compared to subjects in the acute phase of the disease. The difference is made by the results obtained through the Fagerström survey (FTND), where the respondents showed that they mostly sometimes or often have a higher level of nicotine addiction. The hypothesis that a difference in the level of nicotine dependence is expected with regard to the stage of the disease was confirmed. From the data obtained in this research, we can conclude that people with schizophrenia often face multiple challenges, including an increased rate of tobacco smoking, which can increase the risk of physical and mental problems. The expected result that patients in the acute phase of the disease will have a higher level of nicotine addiction compared to patients in stable remission of schizophrenia was confirmed by this research work.