Title Citomorfološke karakteristike atipičnih proliferativnih i malignih promjena u dojci
Title (english) CYTOMORPHOLOGICAL CHARACTERISTICS OF ATYPICAL PROLIFERATIVE AND MALIGNANT BREAST LESIONS
Author Marija Lovrić
Mentor Dinka Šundov (mentor)
Committee member Sonja Koren (predsjednik povjerenstva)
Committee member Merica Glavina Durdov (član povjerenstva)
Committee member Dinka Šundov (član povjerenstva)
Granter University of Split (University Department of Health Studies) Split
Defense date and country 2017-09-14, Croatia
Scientific / art field, discipline and subdiscipline BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract CILJ ISTRAŽIVANJA: utvrditi raspodjelu atipičnih proliferativnih i malignih promjena u dojci u odnosu na dob žene i lokalizaciju promjene u dojci te analizirati sukladnost nalaza citološke analize punktata dojke s konačnom patohistološkom dijagnozom.
ISPITANICI I METODE: U istraživnje su uključene 62 ispitanice s citomorfološkom dijagnozom proliferacije duktalnog epitela s atipijama i malignim tumorom dojke, NCI kategorije C3/C4 i C5. Uzorci su dobiveni punkcijom tankom iglom pod kontrolom ultrazvuka. Obrađeni su i citomorfološki analizirani na Odjelu za kliničku citologiju Kliničkog zavoda za patologiju, sudsku medicinu i citologiju KBC Split od 01. siječnja 2016. do 31. prosinca 2016. godine. Uvidom u medicinsku dokumentaciju prikupljeni su klinički podaci o dobi ispitanica, lokalizaciji tvorbe, citološkoj dijagnozi te patohistološkom nalazu, u ispitanica operiranih na Klinici za kirurgiju KBC Split.
REZULTATI: Atipične proliferativne i maligne promjene u dojci imaju najveću učestalost u dobnoj skupini 60 do 69 godina. Najčešća lokacija lezije je u lijevoj dojci (60%) i u gornjem lateralnom kvadrantu (50%). Od ukupno 62 uzoraka punktata, citomorfološka dijagnoza proliferacije duktalnog epitela s atipijama postavljena je u 23% slučajeva, a dijagnoza malignog tumora dojke u 77% slučajeva. U 76,4% uzoraka patohistološka analiza potvrdila je citomorfološku dijagnozu,od čega se u 99% slučajeva radilo se o citološkoj kategoriji C5. Invazivni duktalni karcinom NOS čini 53% malignih neoplazmi dojke. S obzirom na HR i HER2 status, luminal B HER2 negativni tumor je najzastupljeniji molekularni podtip tumora (41%). Jedan uzorak s citološkom dijagnozom malignog tumora dojke bio je lažno pozitivan. Citološko-patološko neslaganje utvrđeno je u 20% slučajeva, najvećim dijelom u NCI kategoriji C3 i C4 koja uključuje atipične i suspektne citomorfološke slike.
ZAKLJUČAK: Punkcija tankom iglom pod kontrolom UZV-a i citomorfološka analiza vrijedan su standard u trodjelnoj dijagnostičkoj obradi lezija dojke. Lezije „sive zone“ uključuju benigne i maligne lezije dojke i odgovorne su za citološko patološko neslaganje u 20% slučajeva.
Abstract (english) OBJECTIVES: The aim of the study was to analyze the distribution of atipical proliferative and malignant breast lesions according to the age and localization, as well as to determine validity of cytological analysis in relation to final pathohistological diagnosis.
PATIENTS AND METHODS: The study included 62 patients with cytomorphological diagnosis of atypical proliferative and malignant breast lesions, NCI categories C3/4 and C5. The samples were obtained by fine needle aspiration under ultrasound control and analyzed at the Department of Clinical Cytology Clinical Hospital Center Split, from January 1st, 2016 till December 31st, 2016. Clinical data including age and localization of the lesions with cytological and pathohistological diagnosis were collected from the medical records in patients treated at the Department of Surgery, University Hospital of Split.
RESULTS: Atypical proliferative and malignant breast lesions have the highest incidence in the age group 60 to 69 years. The most common location was in the left breast (60%) and upper outer quadrant (50%). Out of a total of 62 cases, atypical proliferative breast lesion was diagnosed in 23% FNA samples and malignant breast lesion was diagnosed in 77% FNA samples. Cytomorphological diagnosis was confirmed pathohistologicaly in 76,4% (42/55) cases, mostly in C5 category (99%) Invasive ductal carcinoma NOS accounted for 53% of malignant breast carcinoma. According to HR i HER2 status, luminal B HER2 negative was the most common molecular subtype (41%). Cytological diagnosis of malignant breast tumor was false positive in one case. Cytological-pathological disagreement was present in 20% of cases, mostly in NCI category C3 and C4, involving atypical and suspected lesions.
CONCLUSION: Fine needle aspiration under the ultrasound control with cytomorphological analysis is valuable standard in the „triple diagnostic procedure“s of breast lesions. The „grey zone“ breast lesions comprise both benign and malignant lesions and are responible for the cytological-histological disconcordance in 20% of cases.
Keywords
citomorfološke metode
atipično
maligne (ključne riječi unio urednik)
Keywords (english)
cytomorphological methods
atypical
malignant (ključne riječi unio urednik)
Language croatian
URN:NBN urn:nbn:hr:176:835584
Study programme Title: Medical Laboratory Diagnostics (university/undergraduate) Study programme type: university Study level: undergraduate Academic / professional title: sveučilišni prvostupnik/prvostupnica (baccalaureus/baccalaurea) medicinska laboratorijska dijagnostika (sveučilišni prvostupnik/prvostupnica (baccalaureus/baccalaurea) medicinska laboratorijska dijagnostika)
Type of resource Text
File origin Born digital
Access conditions Open access
Terms of use
Created on 2020-04-28 08:45:09