Multiple pregnancies are defined as a simultaneous development of more than one fetus in the uterus. The number and frequency of pregnancies with multiple fetuses are constantly increasing due to the increasing number of assisted reproduction. Twins develop from two separate or from the one common ovarian cell. The fertilisation of several different ovary cells may result in triplets, quadruplets, quintuplets or even a larger number of fetuses, but such pregnancies are extremely rare. Diagnosis of multiple pregnancy is based on anamnesis, a clinical signs and the most important, ultrasound examination. Multiple pregnancies are considered as a risky pregnancies because of numerous complications. They are one of the leading public health problems. Numerous complications can affect both mother and children during the pregnancy and childbirth. Quality antenatal care is very important for healthy pregnancy. Most complications which threaten pregnancy can be recognized, diagnosed and cured during the antenatal period. The most important function of midwife during the antenatal period is education of pregnant woman and her family. Delivery of multiple pregnancies is usually spontaneous and without complications but it`s very important to be very careful. On what way twins will be delivered depends mostly on their position inside the uterus. The most favorable position for vaginal birth is when the both babies are head down. Midwife besides physically must also prepare psychically a pregnant woman for delivery. Pleasant conversation can calm and encourage pregnant woman and achieve that she has a great confidence in the entire staff. During the labor, midwife care is based on constant monitoring of pregnant woman and her twins. Midwife will put intravenosus cannula, measure body temperature and blood pressure and empty the bladder . Twins are under constant CTG surveillance. If it`s possible, woman is encouraged to get up from bed and change her position. After delivery, midwife actively participate in the third stage of delivery. Midwife follows signs of placental separation, participates in placenta delivery and prepares placenta(s) for inspection. It`s important to monitor the condition of the mother due to high risk for bleeding and uterine atony. First care of newborns is done in the delivery room. Umbilical cord is clamped and cut, children are measured in lenght and weight and if their condition permits they are put on mothers breast in „skin to skin“ contact. During fourth stage of delivery mother and children are actively monitored but they are also able to rest and get to know each other.