Mood disorders are the most common "major psychiatric disorders." Prevalence BAP in the population is 1%. Like most do not know the exact caused but we can still share into three major categories: biological, psychological and social. Bipolar affective disorder characterized by changes: depression, hypomania, manic and mixed episode. Basic pharmacological therapy is therapy that is primarily performed mood stabilisers. In case of inadequate response to the first drug of choice for lithium as well as some other alternative combinations of newer generation antipsychotics, antidepressants and EST. Lithium, valproic, carbamazepin, and antipsychotics are streamlined in treatment of mania while lamotrigine is streamlined treatment depression. Olazapine is the first antipsychotic approved for the treatment of bipolar affective disorder. Antidepressants monotherapy is not recommended, but in combination with mood stabilizers. Except pharmacological therapy treatment of bipolar affective disorder is implemented and cognitive-behavioral and individual treatment. Bipolar affective disorder is one of the leading psychiatric disorders with the most suicide. Stigmatization for some patients worse than the disease it self, because stigmatization reinforces the sense of alienation, lack of understanding of the environment and causing guilt in patients which affects the flow bolesti. In fight stigmatization are antistigmatization programs to educate that stigmatization must trumpet replaced by tolerance and understanding. An important role has therapeutic relationship nurse and a patient who can have iatrogenic effects that we can not ignore.