Development more than one fetus in woman uterus is called multiple pregnancy. Twins can develop from one or more fertilised egg cells. Multiple pregnancy is considered as high risk pragnancy because of it's higher percentage of complications, specially with one egg twins. Diagnostic is based on anamnesis, clinical exams and most important ultrasound exams. The body of pregnant woman in multiple pregnancy is adjusting the same way as it does for one fetus, but changes are more prominent. There are typical complications such as increased mortality, discordant twins, anastomosis and acardium. The importance of antenatal care is great and it's purpose is to prevent premature birth, recognize intrauterine growth disorders, timely delivery in case of indications, reduced risk of birth defects during childbirth and nursing care for newborn. The most common presentation of twins is both with head or first twin head and second pelvis. In that case vaginal birth is possible if there is no other complications. The role of midwife is very important for woman in labor. From receiving woman to delivery room, educating her about right techniques for breathing and pushing, aplly prescribed therapy, constant monitoring and timely detection of complications, to delivery and first supply of the newborn.