Prostate cancer, today, is one of the leading problems with a high incidence rate. It is one of the most common cancers types and causes of death in many countries. Prostate cancer is a slow growing tumor and in most cases there are no symptoms. It is discovered only with an autopsy in a large percentage of male population. It is less common in the younger population and its frequency increases with age. Because of the high incidence, a program for early detection of prostate cancer was developed with the help of prostate specific antigen (PSA). In addition to PSA values, digitorectal examination and biopsy are also very important. As with other malignancies, the chances of a cure are higher when the tumor is detected in time. The choice of treatment primarily depends on the degree of tumor spread, the general condition of the patient, concomitant diseases and available treatment modalities considering the effectiveness and toxicity of the applied therapy. Radiotherapy is a common way to treat localized and locoregional enlarged prostate cancer with a curative goal, and is also often used in advanced disease as a palliative method of treatment. Due to the rapid development of technology and radiotherapy techniques, they have made significant progress in recent decades. Thanks to our better understanding of the radiobiology of prostate tumors, knowledge of the low α / β ratio, and the radioresistant nature of prostate cancer, different approaches to fractional radiation have been developed. Hypofractionated radiation and stereotactic body radiotherapy are newer methods of teleradiotherapy. The goal of hypofractionation is to reduce the total treatment time (which is very important to the patient), to increase the radiation dose per fraction in order to better control the disease and maintain quality of life during and after treatment. The advantages and disadvantages of such an approach have been proven by many studies. Some details have not yet been defined, but research is still ongoing. Newer methods of hypofractionation with protons and carbon ions have shown even better disease control results, but the cost of devices and treatments prevents the globalization of it’s use.