prikaz prve stranice dokumenta Mismatch repair geni u glioblastomu
  Download
PDF 1.13 MB
undergraduate thesis
Mismatch repair geni u glioblastomu
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2016. urn:nbn:hr:159:453314
Košpić, Karla
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biology and Microbial Genetics

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Košpić, K. (2016). Mismatch repair geni u glioblastomu (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:453314

Košpić, Karla. "Mismatch repair geni u glioblastomu." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2016. https://urn.nsk.hr/urn:nbn:hr:159:453314

Košpić, Karla. "Mismatch repair geni u glioblastomu." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2016. https://urn.nsk.hr/urn:nbn:hr:159:453314

Košpić, K. (2016). 'Mismatch repair geni u glioblastomu', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:159:453314

Košpić K. Mismatch repair geni u glioblastomu [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2016 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:159:453314

K. Košpić, "Mismatch repair geni u glioblastomu", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:159:453314

Metadata
TitleMismatch repair geni u glioblastomu
Title (english)Mismatch repair genes in glioblastoma
AuthorKarla Košpić
MentorReno Hrašćan (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Biology and Microbial Genetics)
Zagreb
Defense date and country2016-09-06, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Cilj ovog rada je dati osvrt na dosadašnja saznanja o ulozi mismatch repair gena (MMR) u jednom od najsmrtonosnijih tumora mozga - multiformnom glioblastomu (GBM). Do sada je poznato kako manjak aktivnosti MMR gena može uzrokovati nastanak tumora, te da je mikrosatelitna nestabilnost u većini slučajeva vezana uz mutacije na MMR genima, no nije otkrivena kod svih tumora. Nadalje, u vezu su stavljeni utjecaji ekspresije MGMT gena i gubitka MMR gena na pojavu recidiva GBM-a kao i na pojavu rezistencije na temozolomid. Naposljetku, dobiven je uvid u nova istraživanja o mogućim primjenama MMR gena u liječenju glioblastoma, a uključuju koncepte sintetičke letalnosti i primjene genske terapije.
Abstract (english)
The aim of this work was to give a review of on record findings of the role of mismatch repair genes (MMR) in the most lethal tumor known - the glioblastoma multiforme (GBM). It is known that the MMR deficiency can cause tumor growth and that it is partly related to the occurrence of the microsatellite instability, but the same phenomenon is not discovered in all tumor samples. Furthermore, the role of MGMT expression as well as MMR deficiency has been investigated in order to find out the mechanisms of GBM recurrence and also development of temozolomide resistance. Ultimately, we have got an insight of possible MMR applications in treating GBM, which includes the concept of synthetic lethality and also application of gene therapy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:453314
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-04-24 08:09:08