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undergraduate thesis
Ugljikohidratni peptidomimetici
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. urn:nbn:hr:159:415645
Rogan, Iva
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Rogan, I. (2012). Ugljikohidratni peptidomimetici (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:415645

Rogan, Iva. "Ugljikohidratni peptidomimetici." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. https://urn.nsk.hr/urn:nbn:hr:159:415645

Rogan, Iva. "Ugljikohidratni peptidomimetici." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. https://urn.nsk.hr/urn:nbn:hr:159:415645

Rogan, I. (2012). 'Ugljikohidratni peptidomimetici', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:159:415645

Rogan I. Ugljikohidratni peptidomimetici [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2012 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:159:415645

I. Rogan, "Ugljikohidratni peptidomimetici", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:159:415645

Metadata
TitleUgljikohidratni peptidomimetici
Title (english)Carbohydrate peptidomimetics
AuthorIva Rogan
MentorLidija Barišić (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2012-07-25, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Organski kemičari koriste metode kombinatorne kemije u kreiranju novih molekularnih građevnih elemenata s ciljem oponašanja strukture i svojstava njihovih prirodnih analoga. Korištenje peptida kao lijekova ograničeno je zbog (i) moguće proteolize u gastrointestinalnom traktu i krvnom serumu te (ii) gubitka nativne konformacije nakon modifikacije peptida. Rješenje predstavlja korištenje krutih, nepeptidnih kalupa koji nakon umetanja u peptid djeluju kao začetnici sekundarne strukture neophodne za njegovo vezivanje za receptor. Raznovrsnost ugljikohidrata u prirodi (anomerna stereokemija, veličina rigidnog prstena, moguća zaštita hidroksilnih skupina čime se utječe na polarnost) čini ih idealnim kandidatima za takve kalupe. Ugljikohidratni peptidomimetici pokazuju i veću otpornost prema proteolizi nego njihovi prirodni analozi.
Abstract (english)
Organic chemists use combinatorial approach to create diverse molecular building blocks. The main objective in developing of such libraries is to mimic the structures and properties of natural products. The use of peptides as drugs is limited due to their low metabolic stability towards proteolysis and loss of its original conformation once truncated from the native protein. New combinatorial strategies involve the design of conformationally rigid nonpeptide scaffolds capable to induce specific secondary structures required for binding to the corresponding receptor upon inserting in the appropriate sites of the peptide. The great diversity of carbohydrates (anomeric stereochemistry, the rigid ring size, protection of hydroxylic groups that influence the polar character) makes themselves as ideal candidates. Compounds made of such building blocks are also more stable towards proteolysis in physiological systems.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:415645
Study programmeTitle: Nutrition
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-15 08:09:33