prikaz prve stranice dokumenta Asimetrična redukcija ketona pomoću natrijeva tetrahidroborata, kvasca S. cerevisiae i azuki graha
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undergraduate thesis
Asimetrična redukcija ketona pomoću natrijeva tetrahidroborata, kvasca S. cerevisiae i azuki graha
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. urn:nbn:hr:159:518356
Železnjak, Jelena
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Cell Technology, Application and Biotransformations

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Železnjak, J. (2012). Asimetrična redukcija ketona pomoću natrijeva tetrahidroborata, kvasca S. cerevisiae i azuki graha (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:518356

Železnjak, Jelena. "Asimetrična redukcija ketona pomoću natrijeva tetrahidroborata, kvasca S. cerevisiae i azuki graha." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. https://urn.nsk.hr/urn:nbn:hr:159:518356

Železnjak, Jelena. "Asimetrična redukcija ketona pomoću natrijeva tetrahidroborata, kvasca S. cerevisiae i azuki graha." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. https://urn.nsk.hr/urn:nbn:hr:159:518356

Železnjak, J. (2012). 'Asimetrična redukcija ketona pomoću natrijeva tetrahidroborata, kvasca S. cerevisiae i azuki graha', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 27 August 2024, https://urn.nsk.hr/urn:nbn:hr:159:518356

Železnjak J. Asimetrična redukcija ketona pomoću natrijeva tetrahidroborata, kvasca S. cerevisiae i azuki graha [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2012 [cited 2024 August 27] Available at: https://urn.nsk.hr/urn:nbn:hr:159:518356

J. Železnjak, "Asimetrična redukcija ketona pomoću natrijeva tetrahidroborata, kvasca S. cerevisiae i azuki graha", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:159:518356

Metadata
TitleAsimetrična redukcija ketona pomoću natrijeva tetrahidroborata, kvasca S. cerevisiae i azuki graha
Title (english)Asymmetric reduction of a ketone by sodium tetrahydroborate, yeast S. cerevisiae and adzuki bean
AuthorJelena Železnjak
MentorJasna Vorkapić-Furač (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Cell Technology, Application and Biotransformations)
Zagreb
Defense date and country2012-07-25, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
U ovom je radu provedena asimetrična redukcija 4-hidroksiacetofenona u 1-(4-hidorksifenil)etanol u vodi kao zelenom otapalu, pomoću kvasca Saccharomyces cerevisiae i azuki graha (Vigna angularis) kao zelenim biokatalizatorima. Navedeni biokatalizatori su pomoću svojih enzima izveli asimetričnu redukciju supstrata, čime se pokazala njihova povoljna uporaba u biotransformacijama prema principima zelene kemije. Radi usporedbe enantioselektivnosti, izvedena je redukcija 4-hidroksiacetofenona u 1-(4-hidroksifenil)etanol pomoću natrijeva tetrahidroborata klasičnom organskom sintezom u etanolu u prisutnosti β-ciklodekstrina. Struktura novosintetiziranog spoja 1-(4-hidroksifenil)etanola određena je IR-spektroskopijom, 1H- i 13C-nuklearnom magnetskom rezonancijom, a apsolutne konfiguracije kiralnog alkohola 1-(4-hidroksifenil)etanola određene su kiralnom HPLC.
Abstract (english)
In this paper novel asymmetric reduction of 4-hydroxyacetophenone into 1-(4-hydroxyphenyl)ethanol was carried out in water as green solvent by using baker's yeast S. cerevisiae and Adzuki bean (Vigna angularis) as green biocatalysts. The enzymes of these biocatalysts preformed the asymmetric reduction of a substrate, showing why they are good for using in biotransformations according to the principles of green chemistry. For comparison of enantioselectivity, the reduction of 4-hydroxyacetophenone into 1-(4-hydroxyphenyl)ethanol with sodium tetrahydroborate in ethanol in the presence of β-cyclodextrin was preformed, too. Structure of novel compound 1-(4-hydroxyphenyl)ethanol was determined by IR spectroscopy, 1H- and 13C-nuclear magnetic resonance, and absolute configurations of chiral alcohol 1-(4-hydroxyphenyl)ethanol by chiral HPLC.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:518356
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
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Created on2017-05-16 09:01:36