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undergraduate thesis
Muramil-peptidi - Struktura i biološka aktivnost
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. urn:nbn:hr:159:403121
Balać, Tanja
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Balać, T. (2012). Muramil-peptidi - Struktura i biološka aktivnost (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:403121

Balać, Tanja. "Muramil-peptidi - Struktura i biološka aktivnost." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. https://urn.nsk.hr/urn:nbn:hr:159:403121

Balać, Tanja. "Muramil-peptidi - Struktura i biološka aktivnost." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. https://urn.nsk.hr/urn:nbn:hr:159:403121

Balać, T. (2012). 'Muramil-peptidi - Struktura i biološka aktivnost', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 21 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:403121

Balać T. Muramil-peptidi - Struktura i biološka aktivnost [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2012 [cited 2024 December 21] Available at: https://urn.nsk.hr/urn:nbn:hr:159:403121

T. Balać, "Muramil-peptidi - Struktura i biološka aktivnost", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:159:403121

Metadata
TitleMuramil-peptidi - Struktura i biološka aktivnost
Title (english)Muramyl peptides - Structure and biological activity
AuthorTanja Balać
MentorLidija Barišić (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2012-06-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Abstract
Bakterijska stanična stijenka sačinjena je iz peptidoglikana (PGN) kojeg izgrađuju brojni glikanski lanci umreženi oligopeptidima. Glikanski lanci sadrže alternirajuće jedinice N-acetilglukozamina (GlcNAc) i N-acetilmuraminske kiseline (MurNAc) kopulirane s prirodnim aminokiselinama. Za vrijeme rasta bakterije, PGN podliježe enzimskoj degradaciji te se raspada na manje fragmente, tzv. muramil-peptide, koji sadrže barem jednu MurNAc i jednu aminokiselinu. Eksperimenti in vitro i in vivo ukazuju na jak utjecaj muramil-peptida na imunosustav. Naime, muramil-peptidi povećavaju otpornost na infekciju aktivirajući makrofage da stavaraju kisikove radikale koji mogu ubiti mikrobe. Budući da su muramilpeptidi prepoznati kao aktivni sastojci kompletnog Freundovog adjuvanta, istraživači su se usredotočili na identificiranje minimalne strukturne komponente neophodne za aktivnost adjuvanta. N-acetilmuramil-L-alanil-D-izoglutamin (muramil-dipeptid, MDP) predstavlja minimalnu strukturnu jedinicu bakterijske stanične stijenke s adjuvantskom aktivnošću.
Abstract (english)
The bacterial cell wall is composed of peptidoglycan (PGN) build up of numerous glycan chains that are cross-linked by oligopeptides. Glycan chains contain alternating Nacetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) subunits, with the amino acids coupled to the MurNAc. During bacterial growing, PGN undergo enzymatic degradation producing fragments named muramyl-peptides that bear at least one MurNAc and one amino acid moieties. Both in vitro and in vivo experiments confirmed strong influence of muramyl-peptides on the immune system. Namely, muropeptides can improve resistance to infection by activating macrophages to generate oxygen radicals which are able to kill microbes. Since muropeptides were recognized as the active components in Freund’s complete adjuvant, researches were focused on identification of minimal structural component required for adjuvant activity. N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl-dipeptide, MDP) represents minimal adjuvant-active subunit of bacterial cell walls.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:403121
Study programmeTitle: Food Technology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
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Created on2017-05-16 13:48:28