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master's thesis
Povezanost jednostrukog nukleotidnog polimorfizma rs1421085 u ljudskom genu FTO s pretilošću žena Zagrebačke županije
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2016. urn:nbn:hr:159:904619
Smolkovič, Barbara
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biology and Microbial Genetics

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Smolkovič, B. (2016). Povezanost jednostrukog nukleotidnog polimorfizma rs1421085 u ljudskom genu FTO s pretilošću žena Zagrebačke županije (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:904619

Smolkovič, Barbara. "Povezanost jednostrukog nukleotidnog polimorfizma rs1421085 u ljudskom genu FTO s pretilošću žena Zagrebačke županije." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2016. https://urn.nsk.hr/urn:nbn:hr:159:904619

Smolkovič, Barbara. "Povezanost jednostrukog nukleotidnog polimorfizma rs1421085 u ljudskom genu FTO s pretilošću žena Zagrebačke županije." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2016. https://urn.nsk.hr/urn:nbn:hr:159:904619

Smolkovič, B. (2016). 'Povezanost jednostrukog nukleotidnog polimorfizma rs1421085 u ljudskom genu FTO s pretilošću žena Zagrebačke županije', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 15 July 2024, https://urn.nsk.hr/urn:nbn:hr:159:904619

Smolkovič B. Povezanost jednostrukog nukleotidnog polimorfizma rs1421085 u ljudskom genu FTO s pretilošću žena Zagrebačke županije [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2016 [cited 2024 July 15] Available at: https://urn.nsk.hr/urn:nbn:hr:159:904619

B. Smolkovič, "Povezanost jednostrukog nukleotidnog polimorfizma rs1421085 u ljudskom genu FTO s pretilošću žena Zagrebačke županije", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:159:904619

Metadata
TitlePovezanost jednostrukog nukleotidnog polimorfizma rs1421085 u ljudskom genu FTO s pretilošću žena Zagrebačke županije
Title (english)Association of single nucleotide polymorphism rs1421085 in human FTO gene with obesity in woman from Zagreb county
AuthorBarbara Smolkovič
MentorVišnja Bačun-Družina (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Biology and Microbial Genetics)
Zagreb
Defense date and country2016-07-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Pretilost je bolest na koju najčešće utječe više čimbenika te interakcije između okolišnih, socijalnih i genetičkih čimbenika. Svrha ovog istraživanja je ispitati potencijalne razlike u sastavu mikrobioma usne šupljine te potencijalni utjecaj genetičkih faktora na razvoj pretilosti genotipizacijom jednostrukog nukleotidnog polimorfizma rs1421085 gena FTO u pretilih žena i žena normalne težine Zagrebačke županije te analizirati njihove prehrambene navike, stil života i zdravstveno stanje. Ispitivanje povezanosti jednostrukog nukleotidnog polimorfizma rs1421085 gena FTO s pretilošću prvo je takve vrste u sjeverozapadnoj Hrvatskoj i općenito drugo dosad u Hrvatskoj što mu daje dodatni značaj. Dobiveni rezultati pokazuju pozitivnu korelaciju između zastupljenosti visokorizičnog genotipa CC rs1421085 gena FTO i pretilosti žena. Također, pronađene su razlike u sastavu mikrobioma usne šupljine pri čemu je bakterijska vrsta Staphylococcus aureus zastupljenija u pretilih žena, dok su u žena normalne tjelesne težine zastupljenije bakterijske vrste roda Streptococcus (S. infantis, S. mitis, S. oralis i S. salivarius) te bakterijska vrsta Serratia ureilytica. Obrada anketnih upitnika ukazuje da pretile žene u povećanoj mjeri konzumiraju hranu bogatu slatkišima i grickalicama te mesom i mesnim prerađevima i učestalije boluju od povišenog krvnog tlaka u odnosu na kontrolnu skupinu žena. Ovim istraživanjem želio se dobiti uvid u postojanje genetičke podloge za povećani rizik od razvoja pretilosti te detektirati mikroorganizme koji su indikator pretilosti kod žena.
Abstract (english)
Obesity is mainly a multifactorial disease caused by interactions between environmental, social and genetic factors. The aims of this study are to investigate possible differences in composition of the oral microbiota and possible influence of the genetic factors on the obesity risk by genotyping single nucleotide polymorphism rs1421085 in the FTO gene in obese and lean women living in Zagreb county and to analyze their eating habits, lifestyle and health condition. This is the first research in the northwest Croatia and the second research in Croatia till now which examines the association of single nucleotide polymorphism rs1421085 in the FTO gene with woman obesity what gives to this research additional value. The results showed the positive correlation between frequency of the high risk genotype CC rs1421085 of the FTO gene and obesity. Moreover, the differences in the composition of the oral microbiota are shown whereby appearance of bacterial species Staphylococcus aureus is higher in obese group. On the other hand, appearances of bacterial species from genus Streptococcus (S. infantis, S. mitis, S. oralis and S. salivarius) and bacterial species Serratia ureilytica are higher in lean group. The questionnaire analysis showed that obese women prefer candy and snacks rich diet and also consume more meat and meat products and have higher hypertension rate compare to lean women. The purposes of this study are to get insight of the existence of the genetic basis of increased obesity risk and to detect the microorganisms which indicate to woman obesity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:904619
Study programmeTitle: Molecular Biotechnology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka molekularne biotehnologije (magistar/magistra inženjer/inženjerka molekularne biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-04-24 10:40:15