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undergraduate thesis
Mutacije kao odgovor bakterija na stres
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2016. urn:nbn:hr:159:753369
Požgajčić, Alen
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biology and Microbial Genetics

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Požgajčić, A. (2016). Mutacije kao odgovor bakterija na stres (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:753369

Požgajčić, Alen. "Mutacije kao odgovor bakterija na stres." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2016. https://urn.nsk.hr/urn:nbn:hr:159:753369

Požgajčić, Alen. "Mutacije kao odgovor bakterija na stres." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2016. https://urn.nsk.hr/urn:nbn:hr:159:753369

Požgajčić, A. (2016). 'Mutacije kao odgovor bakterija na stres', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 15 May 2024, https://urn.nsk.hr/urn:nbn:hr:159:753369

Požgajčić A. Mutacije kao odgovor bakterija na stres [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2016 [cited 2024 May 15] Available at: https://urn.nsk.hr/urn:nbn:hr:159:753369

A. Požgajčić, "Mutacije kao odgovor bakterija na stres", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:159:753369

Metadata
TitleMutacije kao odgovor bakterija na stres
Title (english)Mutations as Bacterial Stress Response
AuthorAlen Požgajčić
MentorVišnja Bačun-Družina (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Biology and Microbial Genetics)
Zagreb
Defense date and country2016-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Bakterije su izložene promjenjivim uvjetima okoliša i zbog toga su razvile mehanizme prilagodbe na stres. Stanice se prilagođavaju tako što započinje ekspresija proteina koji pospješuju adaptaciju na stres preko glavnog regulatora RpoS. Posljedično, povećanje koncentracije RpoS povećava stopu mutacija u stanici. Za takve mutacije uzrokovane stresom je potreban dodatni stres kao što je dvostruki lom DNA koji uzrokuje ekspresiju translezijskih polimeraza koje na kraju rezultiraju uvođenjem mutacija. Ovaj mehanizam mutacije je potencijalno ključan za evoluciju patogenih bakterija, a ujedno i stanica raka zbog sličnih načina popravka u prokariota i eukariota. Razumijevanje puteva kojim mutacije nastaju također otvara nove mogućnosti u biotehnologiji i medicini.
Abstract (english)
Bacteria are exposed to changing environmental conditions and they are equiped with mechanisms of adaptation. Primarily, cells start to express proteins which enhance adaptation to stress through main stress regulator RpoS. Consequently, higher concentration of RpoS increases rate of mutation in a cell. For those stress induced mutations, there is needed additional stress on the molecule of the DNA like double stranded DNA break which causes expression of translesion polymerases that induce mutations in the molecule of the DNA. This mechanism is potentionally key in the evolution of pathogen bacteria and cancer cells because of the similar mismatch repairs in eukaryotes and prokaryotes. Understanding the pathways in which mutations are induced can open new possibilities in biotechnology and medicine.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:753369
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-04-24 10:39:34