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undergraduate thesis
Uloga proteina aksina i beta-katenina u Wnt signalnom putu zdravih stanica i stanica meningeoma
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2017. urn:nbn:hr:159:737236
Grubišić, Ana
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biology and Microbial Genetics

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Grubišić, A. (2017). Uloga proteina aksina i beta-katenina u Wnt signalnom putu zdravih stanica i stanica meningeoma (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:737236

Grubišić, Ana. "Uloga proteina aksina i beta-katenina u Wnt signalnom putu zdravih stanica i stanica meningeoma." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2017. https://urn.nsk.hr/urn:nbn:hr:159:737236

Grubišić, Ana. "Uloga proteina aksina i beta-katenina u Wnt signalnom putu zdravih stanica i stanica meningeoma." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2017. https://urn.nsk.hr/urn:nbn:hr:159:737236

Grubišić, A. (2017). 'Uloga proteina aksina i beta-katenina u Wnt signalnom putu zdravih stanica i stanica meningeoma', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 17 July 2024, https://urn.nsk.hr/urn:nbn:hr:159:737236

Grubišić A. Uloga proteina aksina i beta-katenina u Wnt signalnom putu zdravih stanica i stanica meningeoma [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2017 [cited 2024 July 17] Available at: https://urn.nsk.hr/urn:nbn:hr:159:737236

A. Grubišić, "Uloga proteina aksina i beta-katenina u Wnt signalnom putu zdravih stanica i stanica meningeoma", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:159:737236

Metadata
TitleUloga proteina aksina i beta-katenina u Wnt signalnom putu zdravih stanica i stanica meningeoma
Title (english)The role of Axin and beta-catenin in Wnt signaling pathway in healthy and meningioma cells
AuthorAna Grubišić
MentorReno Hrašćan (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Biology and Microbial Genetics)
Zagreb
Defense date and country2017-09-18, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
U ovom radu su prikazane uloge proteina aksina i β-katenina kao ključnih komponenti Wnt signalnog puta u zdravim stanicama i u meningeomima. Osim što ima ulogu kao glavna signalna molekula Wnt puta, β-katenin je također dio međustaničnih spojeva zajedno s E-kaderinom. Do nastanaka i progresije meningeoma dolazi zbog narušavanja međustaničnih spojeva, tako da će smanjen broj molekula stanične adhezije dovesti do povećane proliferacije tumorskih stanica i može doprinijeti invazivnoj sposobnosti meningeoma. Aksin djeluje kao tumor supresor u karcinomu, ali njegova uloga u meningeomima još nije dovoljno razjašnjena. Ipak, gubitak heterozigotnosti AXIN1 gena u meningeomima može upućivati na njegovu ulogu kao tumor supresora te na posljedično smanjenje razine proteina aksina.
Abstract (english)
This paper studies the roles of β-catenin and Axin as key components of Wnt signaling pathway in healthy and meningioma cells. In addition to having a role as a key signaling molecule of Wnt signaling pathway, β-catenin is also a part of the adherens junctions together with E-cadherin. The occurence and progression of meningiomas are due to disrupted adherens junctions and the decrease in cell adhesion molecules may lead to increased tumor cell proliferation and it may contribute to invasive ability of meningioma. Axin acts as a tumor suppressor in cancer, but its role in meningiomas remains unresolved. However, the loss of heterozygosity of AXIN1 gene in meningiomas may indicate its role as a tumor suppressor and suggest consequent down-regulation of its protein.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:737236
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-09-20 08:02:49