prikaz prve stranice dokumenta Biokemijska i bioloŠka karakterizacija Granzima K i njegova biološka uloga u sistemskoj upali / sepsi
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doctoral thesis
Biokemijska i bioloŠka karakterizacija Granzima K i njegova biološka uloga u sistemskoj upali / sepsi
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2007. urn:nbn:hr:159:492961
Ručević, Marijana
University of Zagreb
Faculty of Food Technology and Biotechnology

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Ručević, M. (2007). Biokemijska i bioloŠka karakterizacija Granzima K i njegova biološka uloga u sistemskoj upali / sepsi (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:492961

Ručević, Marijana. "Biokemijska i bioloŠka karakterizacija Granzima K i njegova biološka uloga u sistemskoj upali / sepsi." Doctoral thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2007. https://urn.nsk.hr/urn:nbn:hr:159:492961

Ručević, Marijana. "Biokemijska i bioloŠka karakterizacija Granzima K i njegova biološka uloga u sistemskoj upali / sepsi." Doctoral thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2007. https://urn.nsk.hr/urn:nbn:hr:159:492961

Ručević, M. (2007). 'Biokemijska i bioloŠka karakterizacija Granzima K i njegova biološka uloga u sistemskoj upali / sepsi', Doctoral thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:492961

Ručević M. Biokemijska i bioloŠka karakterizacija Granzima K i njegova biološka uloga u sistemskoj upali / sepsi [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2007 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:159:492961

M. Ručević, "Biokemijska i bioloŠka karakterizacija Granzima K i njegova biološka uloga u sistemskoj upali / sepsi", Doctoral thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2007. Available at: https://urn.nsk.hr/urn:nbn:hr:159:492961

Metadata
TitleBiokemijska i bioloŠka karakterizacija Granzima K i njegova biološka uloga u sistemskoj upali / sepsi
Title (english)BIOCHEMICAL AND BIOLOGICAL CHARACTERIZATION OF GRANZYME K AND ITS BIOLOGICAL ROLE IN SYSTEMIC INFLAMMATION / SEPSIS
AuthorMarijana Ručević
MBZ: 241373
MentorVladimir Mrša (mentor)
MBZ: 39525
Committee memberĐuro Josić (predsjednik povjerenstva)
MBZ: 307736
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
Zagreb
Defense date and country2007-09-24, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Universal decimal classification
(UDC)		60 - Biotechnology. Genetic engineering. Products of cloning
Abstract
U ovom je radu razvijen kompetitivni Granzim K (GrK) specifični imunotest s ciljem da se istraži uloga te proteaze u sistemskoj upali/sepsi. Utvrđeno je značajno povećanje koncentracije GrK u plazmi pacijenata hitnog odjela s pretpostavljenom dijagnozom sepse, dok je u plazmi pacijenata uključenih u klinički pokus s dijagnosticiranom sepsom utvrđeno značajno smanjenje koncentracije GrK, u usporedbi s kontrolnom skupinom. Slobodni GrK s molekulskom težinom od ~26 kDa uočen je samo u plazmi pacijenata sa sepsom. Rezultati upućuju da bi GrK mogao biti dio patofiziologije sepse te na potencijalnu mogućnost njegova korištenja kao dijagnostičkog biomarkera za stupnjevanje sepse. U radu je započeta i karakterizacija GrK kako bi se razjasnila biološke uloga te moćne proteaze u sistemskoj upali/sepsi.
Abstract (english)
The aim of this study was to investigate the potential role of Granzyme K (GrK) in systemic inflammation/sepsis and therefore a novel GrK-specific immunoassay was developed. The plasma levels of GrK were found increased in patients admitted to the emergency department with a putative diagnosis of sepsis while decreased in patients with severe sepsis enrolled in a clinical trial, compared to healthy subjects. The free GrK as a 26 kDa protein appeared only in patients with sepsis. The results indicate that plasma GrK levels could serve as a useful diagnostic marker to stage sepsis and may play a functional role in the development of sepsis. Characterization of human GrK was also initiated in order to elucidate biological function(s) of this potent serine protease in inflammatory responses/sepsis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:492961
Promotion2008-09-28
Study programmeTitle: Postgraduate PhD Study in Biotechnology and Bioprocess Engineering
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti (doktor/doktorica znanosti)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2018-05-11 12:53:06