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doctoral thesis
Analitički aspekt odabranih ß2-adrenergičkih agonista u tkivu jetre i genotoksikološki učinci na biološkim test sustavima
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2011. urn:nbn:hr:159:205300
Vulić, Ana
University of Zagreb
Faculty of Food Technology and Biotechnology

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Vulić, A. (2011). Analitički aspekt odabranih ß2-adrenergičkih agonista u tkivu jetre i genotoksikološki učinci na biološkim test sustavima (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:205300

Vulić, Ana. "Analitički aspekt odabranih ß2-adrenergičkih agonista u tkivu jetre i genotoksikološki učinci na biološkim test sustavima." Doctoral thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2011. https://urn.nsk.hr/urn:nbn:hr:159:205300

Vulić, Ana. "Analitički aspekt odabranih ß2-adrenergičkih agonista u tkivu jetre i genotoksikološki učinci na biološkim test sustavima." Doctoral thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2011. https://urn.nsk.hr/urn:nbn:hr:159:205300

Vulić, A. (2011). 'Analitički aspekt odabranih ß2-adrenergičkih agonista u tkivu jetre i genotoksikološki učinci na biološkim test sustavima', Doctoral thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 27 November 2024, https://urn.nsk.hr/urn:nbn:hr:159:205300

Vulić A. Analitički aspekt odabranih ß2-adrenergičkih agonista u tkivu jetre i genotoksikološki učinci na biološkim test sustavima [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2011 [cited 2024 November 27] Available at: https://urn.nsk.hr/urn:nbn:hr:159:205300

A. Vulić, "Analitički aspekt odabranih ß2-adrenergičkih agonista u tkivu jetre i genotoksikološki učinci na biološkim test sustavima", Doctoral thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2011. Available at: https://urn.nsk.hr/urn:nbn:hr:159:205300

Metadata
TitleAnalitički aspekt odabranih ß2-adrenergičkih agonista u tkivu jetre i genotoksikološki učinci na biološkim test sustavima
Title (english)Analytical aspect of selected ß2-adrenergic agonists in liver tissue and genotoxicity effects on biological test systems
AuthorAna Vulić
MBZ: 292122
MentorKsenija Durgo (mentor)
MBZ: 226422
Committee memberJasna Franekić (predsjednik povjerenstva)
MBZ: 85870
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
Zagreb
Defense date and country2011-12-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Primjenom validirane LC-MS/MS metode određene su razine ostataka klenbuterola i salbutamola u tkivu jetre nakon subkroničnog tretmana te je potvrđena kumulacija kroz vremensko razdoblje u trajanju od 15 do 30 dana nakon završetka tretmana. Genotoksikološka ispitivanja pokazala su mutageno i prooksidativno djelovanje klenbuterola. Komet testom i analizom kromosomskih aberacija utvrđen je genotoksični učinak klenbuterola i salbutamola dok je genotoksični učinak 4-ADBA utvrđen samo komet testom.
Abstract (english)
By mean of validated LC-MS/MS method the levels of salbutamol and clenbuterol residues in liver tissue after subchronic treatment were determined and accumulation in time period of 15-30 days after treatment withdrawal was confirmed. Genotoxicological tests have shown mutagenic and prooxidative effects of clenbuterol. By mean of Comet assay and chromosome aberrations analysis genotoxic effects of clenbuterol and salbutamol were found while 4-ADBA was found genotoxic only by Comet assay.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:205300
Promotion2012-07-01
Study programmeTitle: Nutrition
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor znanosti/doktorica znanosti (doktor znanosti/doktorica znanosti)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2018-05-16 08:08:16