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master's thesis
Priprava i karakterizacija intermedijera C u sintezi lijeka eltrombopaga
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2016. urn:nbn:hr:159:158852
Zahirović, Ema
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Antibiotic, Enzyme, Probiotic and Starter Cultures Technology

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Zahirović, E. (2016). Priprava i karakterizacija intermedijera C u sintezi lijeka eltrombopaga (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:158852

Zahirović, Ema. "Priprava i karakterizacija intermedijera C u sintezi lijeka eltrombopaga." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2016. https://urn.nsk.hr/urn:nbn:hr:159:158852

Zahirović, Ema. "Priprava i karakterizacija intermedijera C u sintezi lijeka eltrombopaga." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2016. https://urn.nsk.hr/urn:nbn:hr:159:158852

Zahirović, E. (2016). 'Priprava i karakterizacija intermedijera C u sintezi lijeka eltrombopaga', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 29 July 2024, https://urn.nsk.hr/urn:nbn:hr:159:158852

Zahirović E. Priprava i karakterizacija intermedijera C u sintezi lijeka eltrombopaga [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2016 [cited 2024 July 29] Available at: https://urn.nsk.hr/urn:nbn:hr:159:158852

E. Zahirović, "Priprava i karakterizacija intermedijera C u sintezi lijeka eltrombopaga", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:159:158852

Metadata
TitlePriprava i karakterizacija intermedijera C u sintezi lijeka eltrombopaga
Title (english)Preparation and characterization of intermediate C in the synthesis of drug eltrombopag
AuthorEma Zahirović
MentorJagoda Šušković (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Antibiotic, Enzyme, Probiotic and Starter Cultures Technology)
Zagreb
Defense date and country2016-09-22, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Eltrombopag je lijek koji pripada skupini trombopoetin receptor agonista i koristi se za liječenje kronične imunološke trombocitopenije. Cilj ovog rada bio je razviti proces za sintezu i izolaciju intermedijera C koje će se koristiti kao standard za tekućinsku kromatografiju visoke djelotvornosti (HPLC), pri određivanju kromatografske čistoće intermedijera C u sintezi lijeka eltrombopaga. Istražena je učinkovitost Raney nikal i natrijeva ditionita kao katalizatora na hidriranje spoja BPCA-4 (5'-kloro-2'-hidroksi-3'nitro-[1,1'-bifenil]-3-karboksilna kiselina) u svrhu odabira katalizatora kojim će se dobiti viši prinos i odgovarajuća kromatografska čistoća. Sinteza intermedijera C primjenom natrijevog ditionita kao katalizatora pokazala se kao neučinkovita metoda zbog nezadovoljavajuće kromatografske čistoće produkta (59,99 %) i malog prinosa (26,74 %). Raney nikal se pokazao učinkovitijim katalizatorom za sintezu intermedijera C pa su sva naredna istraživanja provedena s ovim katalizatorom. Uzorak ELTC-1612 može poslužiti kao standard za tekućinsku kromatografiju visoke djelotvornosti (HPLC) pri određivanju kromatografske čistoće tijekom industrijske sinteze lijeka eltrombopaga.
Abstract (english)
Drug eltrombopag is a thrombopoietin agonist receptor for the treatment of chronic immune thrombocytopenia. It is necessary to develop a process for the synthesis and isolation of intermediate C to be used as a standard for high performance liquid chromatography (HPLC) to determine the chromatographic purity of intermediate C in the synthesis of the drug eltrombopag. Efficiency of Raney nickel and sodium dithionite catalyst is tested on the hydrogenation compound BPCA-4 and the optimal catalyst is selected that produces a high yield of the corresponding chromatographic purity. Synthesis of intermediate C by using sodium dithionite as a catalyst proved to be an ineffective method due to unsatisfactory chromatographic product purity (59.99 %) and low yield (26.74 %). Raney nickel proved to be more efficient catalyst for the synthesis of intermediate C so all subsequent studies conducted with this catalyst. Sample ELTC-1612 can serve as a standard for high performance liquid chromatography (HPLC) for the determination of chromatographic purity for the industrial synthesis of the drug eltrombopag.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:158852
Study programmeTitle: Bioprocess Engineering
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka bioprocesnog inženjerstva (magistar/magistra inženjer/inženjerka bioprocesnog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2017-04-25 13:46:23