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undergraduate thesis
Utjecaj polifenolna iz ekstrakta cvijeta trnine na dijabetes tipa 2 u C57BL/6 miša
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2018. urn:nbn:hr:159:865276
Frančić, Tajana
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Food Quality Control
Laboratory for Food Chemistry and Biochemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Frančić, T. (2018). Utjecaj polifenolna iz ekstrakta cvijeta trnine na dijabetes tipa 2 u C57BL/6 miša (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:865276

Frančić, Tajana. "Utjecaj polifenolna iz ekstrakta cvijeta trnine na dijabetes tipa 2 u C57BL/6 miša." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2018. https://urn.nsk.hr/urn:nbn:hr:159:865276

Frančić, Tajana. "Utjecaj polifenolna iz ekstrakta cvijeta trnine na dijabetes tipa 2 u C57BL/6 miša." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2018. https://urn.nsk.hr/urn:nbn:hr:159:865276

Frančić, T. (2018). 'Utjecaj polifenolna iz ekstrakta cvijeta trnine na dijabetes tipa 2 u C57BL/6 miša', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:865276

Frančić T. Utjecaj polifenolna iz ekstrakta cvijeta trnine na dijabetes tipa 2 u C57BL/6 miša [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2018 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:159:865276

T. Frančić, "Utjecaj polifenolna iz ekstrakta cvijeta trnine na dijabetes tipa 2 u C57BL/6 miša", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:159:865276

Metadata
TitleUtjecaj polifenolna iz ekstrakta cvijeta trnine na dijabetes tipa 2 u C57BL/6 miša
Title (english)Influence of Prunus spinosa L. flower extract polyphenols on type-2 diabetes mellitus in C57BL/6 mouse
AuthorTajana Frančić
MentorIrena Landeka Jurčević (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Food Quality Control)
(Laboratory for Food Chemistry and Biochemistry)
Zagreb
Defense date and country2018-07-02, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Brojni dokazi sugeriraju da dijeta bogata polifenolnim spojevima ima mogućnost zaštite od dijabetesa. Ekstrak cvijeta Prunus spinosa L. je bio promatran zbog svog utjecaja na lipidnu peroksidaciju i antioksidativni status kod miševa kod kojih je dijabetes izazvan pomoću alloxana. Promatrani biomarkeri oksidativnog stresa u organima su bili malonilaldehid (MDA) i reducirani glutation (GSH). Primjena ekstrakta cvijeta P. spinosa L. u dozi od 100 mg/kg tjelesne mase na C57BL/6 dijabetičnim miševima tijekom 10 dana je uzrokovala značajnu redukciju povišenih MDA vrijednosti, istovremeno povećavajući aktivnost antioksidativnog enzima (GSH) na dijabetičnim miševima. Promatrano značajno povećanje razine MDA u tkivima jetre i bubrega, kod dijabetičnih miševa, sugerira da dijabetični miševi imaju povećanu koncentraciju slobodnih radikala u usporedbi s normalnim, zdravim miševima. Smanjena aktivnost GSH u jetri i bubrezima tijekom dijabetesa je vjerojatno zbog inaktivacija ili inhibicije enzima i to zbog povećanje proizvodnje aloksan povezanih reaktivnih kisikovih vrsta (ROS). Rezultati ukazuju da ekstrakt cvijeta Prunus spinosa L. može reducirati slobodne radikale povezane s oksidativnim stresom u eksperimentalno izazvanom diabetes mellitus.
Abstract (english)
Significant evidence suggests that polyphenol-rich diets have the ability to protect against diabetes. Extract flower Prunus spinosa L. was investigated for its effects on lipid peroxidation and antioxidant status in alloxan-induced diabetic mice. The investigated biomarkers of oxidative stress in the organs were malondialdehyde (MDA) and reduced glutathione (GSH). Administration of extract of P. spinosa L. flower at a dose of 100 mg/kg body weight to C57BL/6 diabetic mice for 10 days caused significant reduction in the elevated MDA level, while increasing the activity of the antioxidant enzyme (GSH) in diabetic mice. The observed significant elevation in MDA level in liver and kidney tissues of alloxaninduced diabetic mice suggests an intensified free radical generation in diabetic mice compared to the normal mice. The lower activities of GSH observed in liver and kidney during diabetes may be due to the inactivation or inhibition of the enzymes by the increased production of alloxan-generated reactive oxygen species (ROS). Results indicate that the extract flower Prunus spinosa L. can reduce free radical mediated oxidative stress in experimental diabetes mellitus.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:865276
Study programmeTitle: Nutrition
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-07-18 10:21:05