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undergraduate thesis
Hidrazidi kao prekursori za sintezu heterocikličkih, biološki aktivnih spojeva
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2018. urn:nbn:hr:159:736781
Mandić, Iva
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Mandić, I. (2018). Hidrazidi kao prekursori za sintezu heterocikličkih, biološki aktivnih spojeva (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:736781

Mandić, Iva. "Hidrazidi kao prekursori za sintezu heterocikličkih, biološki aktivnih spojeva." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2018. https://urn.nsk.hr/urn:nbn:hr:159:736781

Mandić, Iva. "Hidrazidi kao prekursori za sintezu heterocikličkih, biološki aktivnih spojeva." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2018. https://urn.nsk.hr/urn:nbn:hr:159:736781

Mandić, I. (2018). 'Hidrazidi kao prekursori za sintezu heterocikličkih, biološki aktivnih spojeva', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 10 September 2024, https://urn.nsk.hr/urn:nbn:hr:159:736781

Mandić I. Hidrazidi kao prekursori za sintezu heterocikličkih, biološki aktivnih spojeva [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2018 [cited 2024 September 10] Available at: https://urn.nsk.hr/urn:nbn:hr:159:736781

I. Mandić, "Hidrazidi kao prekursori za sintezu heterocikličkih, biološki aktivnih spojeva", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:159:736781

Metadata
TitleHidrazidi kao prekursori za sintezu heterocikličkih, biološki aktivnih spojeva
Title (english)Hydrazides as precursors for the synthesis of heterocyclic, biologically active compounds
AuthorIva Mandić
MentorVeronika Kovač (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2018-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Abstract
Cilj ovoga rada bila je sinteza ferocenskih hidrazida kao prekursora za dobivanje heterocikličkih pirazolnih derivata kurkumina čija će se biološka aktivnost ispitivati na raznim linijama tumorskih stanica. Sinteza ciljnih spojeva provedena je korištenjem dva postupka (A i B) kako bi se odredila efikasnost pojedinog sintetskog puta na temelju dobivenih iskorištenja produkata. Postupkom A, iz ferocenskih kiselina 1, 2 i 3 HOBt/EDC metodom sintetizirani su ferocenski hidrazidi 7 (37%), 8 (69%) i 9 (66%), a u postupku B, reakcijom metilnih estera ferocenske kiseline 4, 5 i 6 s hidrazin hidratom dobiveni su ferocenski hidrazidi u većim iskorištenjima (7-63%, 8-84%, 9- 82%). Sintetski put B pokazao se efikasnijim, a za oba postupka vrijedi da se veća iskorištenja postižu u reakcijama u kojima karboksilna skupina nije direktno vezana na ferocenski prsten. Strukture dobivenih spojeva potvrđene su IR- i NMR-spektroskopijom.
Abstract (english)
The aim of this thesis was the synthesis of ferrocene hydrazides as precursors for the formation of heterocyclic pyrazole derivatives of curcumin whose biological activity will be tested on different lines of tumor cells. Synthesis of the target compounds was performed by two methods (A and B) to determine the efficiency of a particular synthetic route based on the obtained results. By the method A, ferrocene hydrazides 7 (37%), 8 (69%) and 9 (66%) were synthesized from the ferrocene acids 1, 2 and 3 using HOBt/EDC method. The reactions of ferrocene methyl esters 4, 5 and 6 with hydrazine hydrate (method B) gave ferrocene hydrazides in greater yields (7-63%, 8-84%, 9-82%). The synthetic route B was more efficient, whereas with the both methods greater yields in reactions in which the carboxyl group is not directly bound to ferrocene ring were achieved. The structures of obtained compounds were confirmed by IR- and NMR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:736781
Study programmeTitle: Food Technology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-07-19 11:24:09