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undergraduate thesis
Analiza modela metabolizma folata primjenom programskog paketa CellDesigner
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2018. urn:nbn:hr:159:677606
Malešić, Elena
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Process Engineering
Laboratory for Measurement, Regulation and Automatisation

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Malešić, E. (2018). Analiza modela metabolizma folata primjenom programskog paketa CellDesigner (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:677606

Malešić, Elena. "Analiza modela metabolizma folata primjenom programskog paketa CellDesigner." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2018. https://urn.nsk.hr/urn:nbn:hr:159:677606

Malešić, Elena. "Analiza modela metabolizma folata primjenom programskog paketa CellDesigner." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2018. https://urn.nsk.hr/urn:nbn:hr:159:677606

Malešić, E. (2018). 'Analiza modela metabolizma folata primjenom programskog paketa CellDesigner', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 11 June 2024, https://urn.nsk.hr/urn:nbn:hr:159:677606

Malešić E. Analiza modela metabolizma folata primjenom programskog paketa CellDesigner [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2018 [cited 2024 June 11] Available at: https://urn.nsk.hr/urn:nbn:hr:159:677606

E. Malešić, "Analiza modela metabolizma folata primjenom programskog paketa CellDesigner", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:159:677606

Metadata
TitleAnaliza modela metabolizma folata primjenom programskog paketa CellDesigner
Title (english)Analysis of the folate metabolism model in the CellDesigner software package
AuthorElena Malešić
MentorAna Jurinjak Tušek (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Process Engineering)
(Laboratory for Measurement, Regulation and Automatisation)
Zagreb
Defense date and country2018-09-19, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Prehrana i način života imaju vrlo velik utjecaj na metaboličku homeostazu tj. na sve reakcijske procese koji se odvijaju unutar organizma i održavaju pojedinca zdravim. Nutrijenti su aktivne komponente koje se uključuju u metabolizam te u interakciji s drugim komponentama utječu na metaboličku stabilnost. Primjena metodologije matematičkog modeliranja koristan je i jednostavan alat u analiziranju bioloških procesa te omogućuje dobru podlogu za eksperimentalna istraživanja. U ovom radu provedena je analiza modela 1- ugljik metabolizma posredovanog folatom u programskom paketu CellDesigner. Ispitan je utjecaj različitih početnih koncentracija folata te smanjene aktivnosti enzima metionin sintaze na koncentraciju ostalih metabolita. Primjena računalnog programa CellDesigner pokazala se kao dobar temelj za predviđanje promjena metaboličkih koncentracija i brzina reakcija koje vežemo uz pojedina zdravstvena stanja izazvana vitaminskim deficitom.
Abstract (english)
Diet and life style have significant influence on metabolic homeostasis ie. all reaction processes that take place within the organism and keep the individual healthy. Nutrients are active components that are involved in metabolism and, in the interactions with other components, consequently affect metabolic stability. Mathematical modelling methodology can be usefully and simply applied for analysis of biological processes and provides a good foundation for experimental research. In this paper, analysis of 1-carbon metabolism mediated by folate was carried out in the CellDesigner software package. The effect of different initial folate concentrations and the decreased activity of methionine synthase on the concentration of other metabolites within folate-mediated 1-carbon metabolism have been studied. The application of the CellDesigner software proved to be a good basis for predicting changes in metabolic concentrations and the reaction rate associated with the individual health status caused by vitamin deficiency.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:677606
Study programmeTitle: Nutrition
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-10-10 10:23:17