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undergraduate thesis
Priprava i biološka aktivnost depsipeptida
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. urn:nbn:hr:159:375184
Vlahov, Josipa
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Vlahov, J. (2019). Priprava i biološka aktivnost depsipeptida (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:375184

Vlahov, Josipa. "Priprava i biološka aktivnost depsipeptida." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. https://urn.nsk.hr/urn:nbn:hr:159:375184

Vlahov, Josipa. "Priprava i biološka aktivnost depsipeptida." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. https://urn.nsk.hr/urn:nbn:hr:159:375184

Vlahov, J. (2019). 'Priprava i biološka aktivnost depsipeptida', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:375184

Vlahov J. Priprava i biološka aktivnost depsipeptida [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2019 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:159:375184

J. Vlahov, "Priprava i biološka aktivnost depsipeptida", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:159:375184

Metadata
TitlePriprava i biološka aktivnost depsipeptida
Title (english)Synthesis and biological application of depsipeptides
AuthorJosipa Vlahov
MentorMonika Kovačević (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2019-07-09, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Peptidi čine skupinu spojeva koji se zbog određenih nepovoljnih farmakoloških i biomedicinskih karakteristika, ne mogu koristiti u terapeutske svrhe. Kako bi se poboljšala njihova svojstva u tom smislu, s ciljem kliničke primjene, nastala je skupina spojeva koji se nazivaju peptidomimetici, a oponašaju fizikalna i biokemijska svojstva peptida. Depsipeptidi spadaju u skupinu peptidomimetika, a karakterizira ih zamijena peptidne veze sa esterskom. Osim što se mogu izolirati iz prirodnih organizama kao što su gljive, bakterije i morski organizmi, depsipeptidi se mogu i sintetizirati. Dva načina sinteze koja se najčešće koriste su sinteza u otopini i sinteza na čvrstoj fazi. Depsipeptidi su sve važniji izvor farmakološki aktivnih spojeva koji se koriste za razvoj novih sintetički dobivenih lijekova. Pokuzuju široki sprektar bioloških aktivnosti, a najveći potencijal pokazali su kao antitumorski i antimikrobni agensi.
Abstract (english)
Peptide molecules usually can not be used for therapeutic purposes, due to their unfavourable pharmacological and biomedicinal characteristics. In order to improve their properties, with the intention to provide their therapeutic application, a group of peptidomimetic compounds was created, which mimic the physical and biochemical features of the peptides. Depsipeptides are characterized by the amide-to-ester bond substitution and can be isolated from natural organisms such as fungi, bacteria and marine organisms. Depsipeptides can be synthesized; two methods that are most commonly used are total solution synthesis and solidphase synthesis. Depsipeptides are an increasingly important source of pharmacologically active compounds used to develop new synthetically obtained drugs. They have a wide range of biological activities and have shown the greatest potential as antitumor and antimicrobial agents.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:375184
Study programmeTitle: Nutrition
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-07-26 06:20:02