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undergraduate thesis
Mehanizmi inaktivacije tumor supresorskog gena TP53 u razvitku tumora
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. urn:nbn:hr:159:107760
Martić, Nikolina
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biology and Microbial Genetics

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Martić, N. (2019). Mehanizmi inaktivacije tumor supresorskog gena TP53 u razvitku tumora (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:107760

Martić, Nikolina. "Mehanizmi inaktivacije tumor supresorskog gena TP53 u razvitku tumora." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. https://urn.nsk.hr/urn:nbn:hr:159:107760

Martić, Nikolina. "Mehanizmi inaktivacije tumor supresorskog gena TP53 u razvitku tumora." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. https://urn.nsk.hr/urn:nbn:hr:159:107760

Martić, N. (2019). 'Mehanizmi inaktivacije tumor supresorskog gena TP53 u razvitku tumora', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 17 July 2024, https://urn.nsk.hr/urn:nbn:hr:159:107760

Martić N. Mehanizmi inaktivacije tumor supresorskog gena TP53 u razvitku tumora [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2019 [cited 2024 July 17] Available at: https://urn.nsk.hr/urn:nbn:hr:159:107760

N. Martić, "Mehanizmi inaktivacije tumor supresorskog gena TP53 u razvitku tumora", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:159:107760

Metadata
TitleMehanizmi inaktivacije tumor supresorskog gena TP53 u razvitku tumora
Title (english)Mechanisms of tumor suppressor gene TP53 inactivation in tumor development
AuthorNikolina Martić
MentorReno Hrašćan (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Biology and Microbial Genetics)
Zagreb
Defense date and country2019-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Tumori su nakupine promijenjenih stanica koje nekontrolirano rastu i dijele se, a uklanjanjem uzroka njihove pojave njihovo dijeljenje ne prestaje. U kancerogenezi, skupina gena koja ima bitno značenje su tumor supresorski geni. Jedan od njih je gen TP53 koji kodira za nuklearni fosfoprotein p53 i ima ulogu u regulaciji staničnog ciklusa, apoptozi i staničnom starenju. U normalnim uvjetima TP53 inhibira proliferaciju stanica i nekontrolirano dijeljenje, no pojavom mutacija dolazi do inhibicije njegovog supresorskog djelovanja te to pridonosi pojavi tumora. U ovom radu, naglasak je stavljan na somatske i germinativne mutacije koje utječu na ekspresiju p53, polimorfizme p53 te interakcije s drugim koefektorima poput MDM2 i KAP1 te mikroRNA molekula. Također, naveden je pregled humanih tumora koji sadrže mutacije tumor supresorskog gena TP53 redom prema učestalosti pojave u populaciji.
Abstract (english)
Tumors are masses of tissue that grow abnormally and by removing the cause of their occurrence, their growth does not stop. In cancerogenesis, a group of genes that are of crucial importance are tumor suppressor genes. One of them is the TP53 gene that codes for nuclear phosphoprotein p53 and plays a role in regulating cell cycle, apoptosis and cellular ageing. Under normal conditions, TP53 inhibits cell proliferation and uncontrollable growth, but when mutations occur, it results in inhibition of its suppressor activity and this contributes to the tumor development. In this paper, emphasis is placed on somatic and germinative mutations affecting expression of p53, polymorphisms of p53 and interaction with other coefficients such as MDM2 and KAP1 and microRNA molecules. Also, a review of human tumors containing tumor suppressor TP53 tumor mutations is reported according to the frequency of occurrence in the population.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:107760
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-07-26 07:47:30