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undergraduate thesis
Karakterizacija animalnog modela tauopatije odabranim testovima ponašanja
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. urn:nbn:hr:159:610281
Štampar, Emma
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Antibiotic, Enzyme, Probiotic and Starter Cultures Technology

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Štampar, E. (2019). Karakterizacija animalnog modela tauopatije odabranim testovima ponašanja (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:610281

Štampar, Emma. "Karakterizacija animalnog modela tauopatije odabranim testovima ponašanja." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. https://urn.nsk.hr/urn:nbn:hr:159:610281

Štampar, Emma. "Karakterizacija animalnog modela tauopatije odabranim testovima ponašanja." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. https://urn.nsk.hr/urn:nbn:hr:159:610281

Štampar, E. (2019). 'Karakterizacija animalnog modela tauopatije odabranim testovima ponašanja', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 27 August 2024, https://urn.nsk.hr/urn:nbn:hr:159:610281

Štampar E. Karakterizacija animalnog modela tauopatije odabranim testovima ponašanja [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2019 [cited 2024 August 27] Available at: https://urn.nsk.hr/urn:nbn:hr:159:610281

E. Štampar, "Karakterizacija animalnog modela tauopatije odabranim testovima ponašanja", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:159:610281

Metadata
TitleKarakterizacija animalnog modela tauopatije odabranim testovima ponašanja
Title (english)Characterization of the animal model of tauopathy by using selected behavioral tests
AuthorEmma Štampar
MentorBlaženka Kos (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Antibiotic, Enzyme, Probiotic and Starter Cultures Technology)
Zagreb
Defense date and country2019-09-09, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Sporadična Alzheimerova bolest (AB) najčešća je sekundarna tauopatija. Istraživanja na animalnim modelima AB pokazala su transsinaptičko širenje monomernog, oligomernog i fibrilarnog oblika tau proteina, međutim nije jasno utvrđeno je li takvo širenje popraćeno i predmnijevanim kognitivnim promjenama. Stoga je cilj ovog rada bio odrediti hoće li širenje određenog oblika tau proteina biti povezano s kognitivnim promjenama. Nakon 3 i 6 mjeseci po injiciranju tau proteina u entorinalnu moždanu koru Wistar štakora provedeni su odabrani testovi ponašanja. Rezultati dobiveni nakon provedenih testova ponašanja su pokazali da je kognitivni deficit bio ovisan o obliku injiciranog tau proteina i vremenskoj točci u kojoj je izvršeno testiranje. Tri mjeseca nakon injiciranja, testom otvorenog prostora utvrđeno je anksiozno ponašanje kod skupina životinja kojima su injicirani oligomeri tau proteina i skupina životinja kojima su injicirani kratki filamenti tau proteina. T-labirintom je utvrđen deficit kratkoročnog pamćenja kod skupine fibrili nakon 3 i 6 mj i kod skupine oligomer nakon 6 mj, dok testom prepoznavanja novog objekta nije utvrđen deficit dugoročnog pamćenja ni u jednoj od ispitivanih skupina.
Abstract (english)
Sporadic Alzheimer's Disease (AD) is the most common secondary tauopathy. Research on animal models of AB has shown the trans-synaptic spread of the monomeric, oligomeric, and fibrillar forms of tau proteins. However, it has not been clearly determined whether such propagation parallels presumed cognitive changes. Therefore, the aim of this work was to determine will the spread of tau proteins be accompanied with cognitive changes. Three and six months after injection of tau protein into the entorhinal cortex, selected behavioral tests were performed. Behavior tests results showed that rats exhibited form and time-dependent cognitive deficits. The open field test showed anxiety behavior in the groups receiving the tau oligomer and the groups receiving the tau fibril at 3 m time point. The T-maze test showed a short-term memory deficit in the fibrils group after both 3 and 6 m, and in the oligomer group after 6 m. The novel object recognition test showed no long-term memory deficit in either group.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:610281
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2019-09-11 11:20:24