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undergraduate thesis
Priprema i karakterizacija kopulata ferocenoil klorida i citozina
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. urn:nbn:hr:159:808790
Ostojić, Jelena
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Ostojić, J. (2015). Priprema i karakterizacija kopulata ferocenoil klorida i citozina (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:808790

Ostojić, Jelena. "Priprema i karakterizacija kopulata ferocenoil klorida i citozina." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. https://urn.nsk.hr/urn:nbn:hr:159:808790

Ostojić, Jelena. "Priprema i karakterizacija kopulata ferocenoil klorida i citozina." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. https://urn.nsk.hr/urn:nbn:hr:159:808790

Ostojić, J. (2015). 'Priprema i karakterizacija kopulata ferocenoil klorida i citozina', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 22 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:808790

Ostojić J. Priprema i karakterizacija kopulata ferocenoil klorida i citozina [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2015 [cited 2024 December 22] Available at: https://urn.nsk.hr/urn:nbn:hr:159:808790

J. Ostojić, "Priprema i karakterizacija kopulata ferocenoil klorida i citozina", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:159:808790

Metadata
TitlePriprema i karakterizacija kopulata ferocenoil klorida i citozina
Title (english)Synthesis and characterization of cytosine's ferrocene compounds
AuthorJelena Ostojić
MentorSenka Djaković (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2015-07-08, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Abstract
Organometalni spojevi koji sadrže atom željeza, feroceni, poznati su po svom širokom spektru biološkog djelovanja. Reagirajući s biomolekulama, posebice s DNA, nastaju kopulati koji su pokazali antitumorsko djelovanje in vivo, te antibakterijsko i antiviralno djelovanje. U okviru ovog završnog rada pripravljen je kopulat koji nastaje povezivanjem ferocenoila i nukleobaze citozina preko amino skupine (NH2) vezane na C4-atom citozina. Njegova je struktura potvrĎena primjenom IR, 1H i 13C NMR spektroskopije. U daljnjem tijeku istraživanja potrebno je zaštiti amino skupinu citozina prije deprotekcije ili promijeniti reakcijske uvjete kako bi došlo do usmjeravanja reakcije u N1-položaj.
Abstract (english)
Iron-containing organometallic compounds, ferrocenes, are known to exhibit a wide range of biological activities. Interactions between ferrocenes and biomolecular targets, especially DNA, result with conjugates which have shown antitumor capability when studied in vivo and also antibacterial and antiviral activities. In this final work, conjugate was prepared by reaction of ferocenoil and nucleobase cytosine on the amino group (NH2) linked to C4-atom of the base. The structure of conjugate was confirmed by IR, 1H- and 13C-NMR spectroscopy. In further research, it is necessary to protect amino group before deprotection or to change reaction conditions in order to direct the reaction into N1-position.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:808790
Study programmeTitle: Food Technology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-04-26 09:33:17