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undergraduate thesis
Ferocenski asimetrični kurkuminoid-pirazoli: sinteza i strukturna karakterizacija
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. urn:nbn:hr:159:081414
Lukačević, Tea
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Lukačević, T. (2019). Ferocenski asimetrični kurkuminoid-pirazoli: sinteza i strukturna karakterizacija (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:081414

Lukačević, Tea. "Ferocenski asimetrični kurkuminoid-pirazoli: sinteza i strukturna karakterizacija." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. https://urn.nsk.hr/urn:nbn:hr:159:081414

Lukačević, Tea. "Ferocenski asimetrični kurkuminoid-pirazoli: sinteza i strukturna karakterizacija." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. https://urn.nsk.hr/urn:nbn:hr:159:081414

Lukačević, T. (2019). 'Ferocenski asimetrični kurkuminoid-pirazoli: sinteza i strukturna karakterizacija', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 05 August 2024, https://urn.nsk.hr/urn:nbn:hr:159:081414

Lukačević T. Ferocenski asimetrični kurkuminoid-pirazoli: sinteza i strukturna karakterizacija [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2019 [cited 2024 August 05] Available at: https://urn.nsk.hr/urn:nbn:hr:159:081414

T. Lukačević, "Ferocenski asimetrični kurkuminoid-pirazoli: sinteza i strukturna karakterizacija", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:159:081414

Metadata
TitleFerocenski asimetrični kurkuminoid-pirazoli: sinteza i strukturna karakterizacija
Title (english)Ferrocene-containing asymmetric curcuminoid pyrazoles: synthesis and structure characterization
AuthorTea Lukačević
MentorVeronika Kovač (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2019-09-18, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Kurkumin, glavni polifenolni spoj prisutan u korijenu biljke Curcuma longa, posjeduje razna farmakološka svojstva. Unatoč brojnim pozitivnim djelovanjima, iskorištenje kurkumina u organizmu je iznimno nisko te su provedena mnoga istraživanja kako bi se poboljšala njegova biodostupnost pri čemu glavnu ulogu ima sinteza strukturnih analoga kurkumina. Cilj ovoga rada je sinteza i strukturna karakterizacija novih ferocenom deriviranih kurkuminoid-pirazola u svrhu ispitivanja njihove antioksidativne, antimikrobne i antitumorne aktivnosti te usporedbe s aktivnošću koju pokazuje kurkumin. Za sintezu analoga kurkumina korišten je ferocenilaceton (1), ferocenski spoj koji je ranije poznat u literaturi. Sintetizirani su sljedeći novi spojevi: ferocenski β-diketonski analog kurkumina 2 te ferocenski kurkuminoid-pirazoli 3, 4 i 5 u sljedećim iskorištenjima: 2-54%, 3-50%, 4-47% i 5-33%. Strukture dobivenih spojeva potvrđene su IR- i NMR-spektroskopijom.
Abstract (english)
Curcumin, the main polyphenol compound found in the rhizome of the plant Curcuma longa, possesses various pharmacological properties. Despite its numerous positive effects, bioavailability of curcumin is extremely poor. Consequently many studies have been conducted in order to improve its bioavailability, wherein the leading role is given to the synthesis of curcumin analogues. The aim of this thesis was the synthesis and structure characterization of new ferrocene derived curcuminoid pyrazoles for the purpose of testing their antioxidant, antimicrobial and antitumor activities in comparison with the biological activities of curcumin. Ferrocenylacetone (1), ferrocene compound formerly mentioned in the literature, was used for the synthesis of curcumin analogues. The following new compounds were synthesized: ferrocene β-diketone curcumin analogue 2 and ferrocene curcuminoid pyrazoles 3, 4 and 5 in the following yields: 2-54%, 3-50%, 4-47% i 5-33%. The structures of obtained compounds were confirmed by IR and NMR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:081414
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-09-23 09:14:02