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undergraduate thesis
Uloga Ras proteina u razvoju feokromocitoma
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. urn:nbn:hr:159:677266
Kobeščak, Maja
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biology and Microbial Genetics

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Kobeščak, M. (2019). Uloga Ras proteina u razvoju feokromocitoma (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:677266

Kobeščak, Maja. "Uloga Ras proteina u razvoju feokromocitoma." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. https://urn.nsk.hr/urn:nbn:hr:159:677266

Kobeščak, Maja. "Uloga Ras proteina u razvoju feokromocitoma." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. https://urn.nsk.hr/urn:nbn:hr:159:677266

Kobeščak, M. (2019). 'Uloga Ras proteina u razvoju feokromocitoma', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 10 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:677266

Kobeščak M. Uloga Ras proteina u razvoju feokromocitoma [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2019 [cited 2024 December 10] Available at: https://urn.nsk.hr/urn:nbn:hr:159:677266

M. Kobeščak, "Uloga Ras proteina u razvoju feokromocitoma", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:159:677266

Metadata
TitleUloga Ras proteina u razvoju feokromocitoma
Title (english)The role of Ras proteins in pheochromocytoma growth
AuthorMaja Kobeščak
MentorReno Hrašćan (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Biology and Microbial Genetics)
Zagreb
Defense date and country2019-09-18, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Feokromocitom je uglavnom benigni tumor kromafinih stanica nadbubrežne žlijezde. Klinička svojstva feokromocitoma pretežno su posljedica prekomjernog lučenja katekolamina, a povišeni krvni tlak najčešća je manifestacija. Razvoj feokromocitoma povezuje se s mutacijama na više od desetak gena. Najčešće se javlja kao posljedica somatskih genskih mutacija, a može biti nasljedan u slučaju embrionalnih mutacija. Ras geni su najčešći onkogeni u ljudskim tumorima. Točkaste mutacije dovode do sinteze Ras proteina bez mogućnosti inaktivacije što uzrokuje neprestanu aktivnost kaskada protein-kinaza aktiviranih mitogenom (MAPK) i signalnog puta fosfatidilinozitol-3-kinaze (PI3-K), zaduženih sa rast, proliferaciju, diferencijaciju i preživljavanje stanica. Mutacije H-Ras proteina otkrivene su u otprilike 7% sporadičnih oblika feokromocitoma. Onkogena aktivacija gena RET i NF1 također može uzrokovati amplifikaciju Ras posredovanih signalnih puteva i rezultirati promijenjenom ekspresijom gena.
Abstract (english)
Pheochromocytoma is mostly benign tumor of adrenal cromaffin cells. Clinical characteristics are mostly the consequence of excessive catecholamine secretion, mainly manifesting as high blood pressure. Pheochromocytoma tumorogenesis is connected with mutation in more than 10 genes. Mostly it is sporadic as result of somatic mutations of some genes, but it can be hereditary in case of germline mutations. Ras genes are the most common human oncogenes. Point mutations are causing synthesis of Ras protein unable to inactivate, leading to constant activation of mitogen-activated protein kinases cascade and phosphatidylinositol-3-kinase signal pathway which are in charge of cell growth, proliferation, differentiation and survival. Mutations of H-Ras protein are found in about 7% of all pheochormocytomas. Oncogenic activation of RET and NF1 genes can also cause amplification of signal pathways mediated by Ras protein and result in changed gene expression.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:677266
Study programmeTitle: Nutrition
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-09-23 09:29:53