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master's thesis
Priprema i karakterizacija ferocenoil uracilnih derivata
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2018. urn:nbn:hr:159:229725
Marić, Ana
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Marić, A. (2018). Priprema i karakterizacija ferocenoil uracilnih derivata (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:229725

Marić, Ana. "Priprema i karakterizacija ferocenoil uracilnih derivata." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2018. https://urn.nsk.hr/urn:nbn:hr:159:229725

Marić, Ana. "Priprema i karakterizacija ferocenoil uracilnih derivata." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2018. https://urn.nsk.hr/urn:nbn:hr:159:229725

Marić, A. (2018). 'Priprema i karakterizacija ferocenoil uracilnih derivata', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 30 June 2024, https://urn.nsk.hr/urn:nbn:hr:159:229725

Marić A. Priprema i karakterizacija ferocenoil uracilnih derivata [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2018 [cited 2024 June 30] Available at: https://urn.nsk.hr/urn:nbn:hr:159:229725

A. Marić, "Priprema i karakterizacija ferocenoil uracilnih derivata", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:159:229725

Metadata
TitlePriprema i karakterizacija ferocenoil uracilnih derivata
Title (english)Synthesis and characterization of ferrocenoyl-uracile derivatives
AuthorAna Marić
MentorJasmina Lapić (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2018-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Nukleozidni analozi supstituirani u položaju C-5 pirimidinskog prstena ističu se snažnim biološkim djelovanjem. S druge strane, kopulati ferocena s nukleobazama postaju sve češći predmet istraživanja zbog svoje izuzetne biološke aktivnost i zanimljivih elektrokemijskih svojstva, zbog čega su pronašli svoje mjesto u različitim granama kemije, posebice u medicinskoj kemiji. Stoga je cilj ovog rada bio sinteza homo- i heteroanularno supstituiranih konjugata ferocena i C-5 supstituiranih derivata uracila kao potencijalno aktivnih supstanci. Posebna pozornost posvećena je ispitivanju utjecaja K2CO3 kao baznog katalizatora i klorida ferocena kao acilirajućih reagensa na iskorištenje i regiselektivnost reakcija. Strukture svih priređenih spojeva su potvrđene spektroskopskim metodama FTIR, 1H i 13C NMR.
Abstract (english)
Nucleoside analouges substituted on C-5 position of the pyrimidyne ring are distinguished by their strong biological effects. On the other hand, copulates of ferrocene with nucleobases become an interesting research subject because of their exceptional biological activity and interesting electrochemical properties, because of which they found their place in different chemistry branches, especially in medicinal chemistry. Therefore, the purpose of this thesis is synthesis of homo- and heteroannularly substituted conjugates of ferrocene with C-5 substituted uracil derivatives as potentially active substances. Special attention is given to testing the effects of K2CO3 as base catalyst, and ferrocene chlorides as acylation reagents on yield and regioselectivity of the reaction. The structures of the prepared compounds were confirmed by spectroscopic methods FTIR, 1H and 13C NMR.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:229725
Study programmeTitle: Bioprocess Engineering
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka bioprocesnog inženjerstva (magistar/magistra inženjer/inženjerka bioprocesnog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-11-15 11:07:33