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master's thesis
Antibakterijski, citotoksični i antioksidativni učinakbenzoksantenskih lignana
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. urn:nbn:hr:159:048952
Žuna, Kristina
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biology and Microbial Genetics

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Žuna, K. (2019). Antibakterijski, citotoksični i antioksidativni učinakbenzoksantenskih lignana (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:048952

Žuna, Kristina. "Antibakterijski, citotoksični i antioksidativni učinakbenzoksantenskih lignana." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. https://urn.nsk.hr/urn:nbn:hr:159:048952

Žuna, Kristina. "Antibakterijski, citotoksični i antioksidativni učinakbenzoksantenskih lignana." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2019. https://urn.nsk.hr/urn:nbn:hr:159:048952

Žuna, K. (2019). 'Antibakterijski, citotoksični i antioksidativni učinakbenzoksantenskih lignana', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 04 August 2024, https://urn.nsk.hr/urn:nbn:hr:159:048952

Žuna K. Antibakterijski, citotoksični i antioksidativni učinakbenzoksantenskih lignana [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2019 [cited 2024 August 04] Available at: https://urn.nsk.hr/urn:nbn:hr:159:048952

K. Žuna, "Antibakterijski, citotoksični i antioksidativni učinakbenzoksantenskih lignana", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:159:048952

Metadata
TitleAntibakterijski, citotoksični i antioksidativni učinakbenzoksantenskih lignana
Title (english)Antibacterial, cytotoxic and antioxidative effects of benzoxanthene lignans
AuthorKristina Žuna
MentorKsenija Durgo (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Biology and Microbial Genetics)
Zagreb
Defense date and country2019-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Benzoksantenski lignani su prirodni spojevi koji su dosad u manjem broju izolirani iz različitih biljaka te se o njihovom biološkom djelovanju ne zna mnogo. Mogu se dobiti i kemijskom sintezom, a u ovom radu su ispitivani antibakterijski, citotoksični i antioksidativni učinci osam benzoksantenskih lignana dobivenih oksidativnim vezanjem kafeinske kiseline i metil kafeata. Iz dobivenih rezultata se može zaključiti da benzoksantenski lignani u koncentracijama od 0,5 i 0,05 mmol L-1 pokazuju značajni antibakterijski učinak na Gram pozitivne bakterije. Također, svi spojevi osim jednog su pokazali značajan citotoksični učinak na stanice humanog karcinoma jetre u koncentraciji od 0,05 mmol L-1 te je dokazana važnost bočnih fenilnih i slobodnih hidroksilnih skupina u njihovoj strukturi za učinkovito inhibiranje rasta tumorskih stanica. Značajan antioksidativni učinak su pokazali svi ispitivani benzoksantenski lignani u koncentraciji od 0,05 mmol L-1, a za antioksidativno djelovanje su bili odgovorni spojevi sa slobodnim hidroksilnim skupinama na položajima 6, 9 i 10 C atoma.
Abstract (english)
Benzoxanthene lignans are natural compounds that have been isolated from various plants, but not very much is known about their biological activity. This study investigated the antibacterial, cytotoxic and antioxidant effects of eight different benzoxanthene lignans synthesized by oxidative coupling of caffeic acid and methyl caffeate. Results showed that all benzoxanthene lignans exhibited significant antibacterial effects against Gram positive bacteria at concentrations of 0,5 and 0,05 mmol L-1. Seven of them showed significant cytotoxic effects on human liver cancer cells at a concentration of 0,05 mmol L-1, with phenyl and hydroxyl groups in the structure being responsible for their effective tumor cell growth inhibition. All benzoxanthene lignans showed significant antioxidative effects at a concentration of 0,05 mmol L-1. C-6, C-9 and C-10 hydroxyl groups were proven to be important for such antioxidative activity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:048952
Study programmeTitle: Molecular Biotechnology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka molekularne biotehnologije (magistar/magistra inženjer/inženjerka molekularne biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2020-02-13 14:44:23