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master's thesis
Modeliranje utjecaja različitih koncentracija glutena na aktivaciju imunoodgovora kod celijakije
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. urn:nbn:hr:159:544502
Remenar, Sandra
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Process Engineering
Laboratory for Measurement, Regulation and Automatisation

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Remenar, S. (2020). Modeliranje utjecaja različitih koncentracija glutena na aktivaciju imunoodgovora kod celijakije (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:544502

Remenar, Sandra. "Modeliranje utjecaja različitih koncentracija glutena na aktivaciju imunoodgovora kod celijakije." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:544502

Remenar, Sandra. "Modeliranje utjecaja različitih koncentracija glutena na aktivaciju imunoodgovora kod celijakije." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:544502

Remenar, S. (2020). 'Modeliranje utjecaja različitih koncentracija glutena na aktivaciju imunoodgovora kod celijakije', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 07 June 2024, https://urn.nsk.hr/urn:nbn:hr:159:544502

Remenar S. Modeliranje utjecaja različitih koncentracija glutena na aktivaciju imunoodgovora kod celijakije [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2020 [cited 2024 June 07] Available at: https://urn.nsk.hr/urn:nbn:hr:159:544502

S. Remenar, "Modeliranje utjecaja različitih koncentracija glutena na aktivaciju imunoodgovora kod celijakije", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:159:544502

Metadata
TitleModeliranje utjecaja različitih koncentracija glutena na aktivaciju imunoodgovora kod celijakije
Title (english)Modelling the influence of different gluten concentrations on immunoresponse activation in celiac disease
AuthorSandra Remenar
MentorAna Jurinjak Tušek (mentor)
Committee memberJasenka Gajdoš Kljusurić (predsjednik povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Process Engineering)
(Laboratory for Measurement, Regulation and Automatisation)
Zagreb
Defense date and country2020-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Celijakija je postala ozbiljan javnozdravstveni problem koji sa sobom nosi brojne popratne bolesti. Prehrana bez glutena trenutno je jedini lijek u borbi protiv te bolesti. U ovome radu proveden je dizajn i simulacije modela imunološkog odgovora kod celijakije u programskom paketu CellDesigner. Ispitan je utjecaj različitih početnih koncentracija glutena nakon čega se pratila koncentracija metabolita, odnosno jačina imunoodgovora. Početne koncentracije određene su na temelju osmišljenih jelovnika za opću populaciju i za osobe oboljele od celijakije. Određeni su ključni kinetički parametri modela analizom globalne i lokalne osjetljivosti. Matematičko modeliranje pokazalo se vrlo korisnim u razumijevanju složenih metaboličkih procesa unutar stanica.
Abstract (english)
Celiac disease has become a serious public health problem that carries with it a number of comorbidities. A gluten-free diet is currently the only cure for this disease. In this paper, the design and simulations of the immune response model in celiac disease in the CellDesigner software package were performed. The influence of different initial gluten concentrations was examined, after which the concentration of metabolites, and the strength of the immune response was monitored. Initial concentrations were determined on the basis of designed menus for the general population and for people with celiac disease. Key kinetic parameters of the model were determined by global and local sensitivity analysis. Mathematical modelling has proven to be very useful in understanding complex metabolic processes within cells.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:544502
Study programmeTitle: Nutrition
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) icon
Created on2020-07-20 12:04:55