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master's thesis
Analiza modela metabolizma triptofana
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. urn:nbn:hr:159:977054
Karatović, Anja
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Process Engineering
Laboratory for Measurement, Regulation and Automatisation

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Karatović, A. (2020). Analiza modela metabolizma triptofana (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:977054

Karatović, Anja. "Analiza modela metabolizma triptofana." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:977054

Karatović, Anja. "Analiza modela metabolizma triptofana." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:977054

Karatović, A. (2020). 'Analiza modela metabolizma triptofana', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 29 July 2024, https://urn.nsk.hr/urn:nbn:hr:159:977054

Karatović A. Analiza modela metabolizma triptofana [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2020 [cited 2024 July 29] Available at: https://urn.nsk.hr/urn:nbn:hr:159:977054

A. Karatović, "Analiza modela metabolizma triptofana", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:159:977054

Metadata
TitleAnaliza modela metabolizma triptofana
Title (english)Analysis of model of tryptophan metabolism
AuthorAnja Karatović
MentorAna Jurinjak Tušek (mentor)
Committee memberJasenka Gajdoš Kljusurić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Process Engineering)
(Laboratory for Measurement, Regulation and Automatisation)
Zagreb
Defense date and country2020-07-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Matematičko modeliranje daje nam na jednostavan i ponovljiv način detaljan uvid na metaboličke procese koji se zbivaju u stanicama. Metabolizam triptofana uglavnom se odvija preko kinureninskoga puta pri kojem nastaju metaboliti zajedničkoga naziva kinurenini. U ovom radu provedena je analiza modela metabolizma triptofana programima CellDesigner i WR Mathematica. Primjenom analize parametarske osjetljivosti identificirane su najosjetljivije reakcije modela. Rezultati provedene analize pokazuju da su reakcija sinteze proteina i reakcije transporta triptofana između cirkulacije i pojedinih tkiva najosjetljivije reakcije u modelu. Enzim aril formamidaza (AFD) uključen u kinureninski put pokazao se kao ključni enzim za analizirani model metabolizma. Ovaj model uspješno simulira metabolizam triptofana kinureninskim putem te se može koristiti za buduća eksperimentalna istraživanja.
Abstract (english)
Mathematical modeling gives us a simple and reproducible detailed insight into the metabolic processes that take place in cells. Tryptophan metabolism is mainly happening via the kynurenin pathway, which produces metabolites collectively known as kynurenines. In this paper the analysis of tryptophan metabolism model was performed by CellDesigner and WR Mathematica. By applying parametric sensitivity analysis, the most sensitive reactions of the model were identified. The results of the analysis show that the protein synthesis reaction and the tryptophan transport between the circulation and individual tissues are the most sensitive reactions in the model. The enzyme aryl formamidase (AFD) involved in the kynurenine pathway has been shown to be a key enzyme for the analyzed metabolism model. This model successfully simulates tryptophan metabolism by the kynurenin pathway and can be used for future experimental research.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:977054
Study programmeTitle: Nutrition
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) icon
Created on2020-07-22 09:17:09