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undergraduate thesis
Priprava i konformacijska analiza ferocenskog dipeptida Boc-L-Pro-Fca-OMe
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. urn:nbn:hr:159:777338
Tarandek, Ana
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Tarandek, A. (2020). Priprava i konformacijska analiza ferocenskog dipeptida Boc-L-Pro-Fca-OMe (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:777338

Tarandek, Ana. "Priprava i konformacijska analiza ferocenskog dipeptida Boc-L-Pro-Fca-OMe." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:777338

Tarandek, Ana. "Priprava i konformacijska analiza ferocenskog dipeptida Boc-L-Pro-Fca-OMe." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:777338

Tarandek, A. (2020). 'Priprava i konformacijska analiza ferocenskog dipeptida Boc-L-Pro-Fca-OMe', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:777338

Tarandek A. Priprava i konformacijska analiza ferocenskog dipeptida Boc-L-Pro-Fca-OMe [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2020 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:159:777338

A. Tarandek, "Priprava i konformacijska analiza ferocenskog dipeptida Boc-L-Pro-Fca-OMe", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:159:777338

Metadata
TitlePriprava i konformacijska analiza ferocenskog dipeptida Boc-L-Pro-Fca-OMe
Title (english)Preparation and conformational analysis of ferrocene dipeptide Boc-L-Pro-Fca-OMe
AuthorAna Tarandek
MentorMonika Kovačević (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2020-09-01, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
U ovom završnom radu opisani su priprava i konformacijska svojstva ferocenskog dipeptida 1 (Boc-L-Pro-Fca-OMe) koji se pripravlja kopulacijom ferocenske aminokiseline (Fca, I) s L-Pro primjenom standardnog HOBt/EDC postupka. Da bi se ispitao utjecaj uvođenja prolina na tvorbu intramolekulskih vodikovih veza (IHB), te posljedično i na konformacijski prostor koji ferocenski dipeptid zauzima u otopini, provedena je spektroskopska analiza (IR-, NMR- i CD-spektroskopija). Kristalografskom analizom ispitana je mogućnost tvorbe IHB u čvrstom stanju. Pokazalo se da u čvrstom stanju, kao i u otopini dolazi do tvorbe IHB veze koja rezultira 7-članim prstenom, odnosno γ-okretom.
Abstract (english)
The research conducted in this work includes the preparation and structural characterization of ferrocene dipeptide 1 (Boc-L-Pro-Fca-OMe), by copulation ferrocene amino acid (Fca, I) and L-Pro using standard HOBt/EDC method. To examine the effect of proline introduction on formation of intramolecular hydrogen bond (IHB) in solution, the detailed conformational analysis (IR, NMR- and CD-spectroscopy) in solution was performed. Crystallographic structure of dipeptide 2 in solid state was determined to explore possibility of IHB formation. It has been shown that the formation of intramolecular hydrogen bonding in solid state occurs, forming 7-membered ring, i.e. γ-turn. Same pattern is retained in solution state.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:777338
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2020-10-29 14:39:27