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master's thesis
Stanični ciklus i smrt stanice u proizvodnoj staničnoj liniji
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. urn:nbn:hr:159:613160
Ivanić, Ana
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Cell Technology, Application and Biotransformations

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Ivanić, A. (2020). Stanični ciklus i smrt stanice u proizvodnoj staničnoj liniji (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:613160

Ivanić, Ana. "Stanični ciklus i smrt stanice u proizvodnoj staničnoj liniji." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:613160

Ivanić, Ana. "Stanični ciklus i smrt stanice u proizvodnoj staničnoj liniji." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:613160

Ivanić, A. (2020). 'Stanični ciklus i smrt stanice u proizvodnoj staničnoj liniji', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 10 September 2024, https://urn.nsk.hr/urn:nbn:hr:159:613160

Ivanić A. Stanični ciklus i smrt stanice u proizvodnoj staničnoj liniji [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2020 [cited 2024 September 10] Available at: https://urn.nsk.hr/urn:nbn:hr:159:613160

A. Ivanić, "Stanični ciklus i smrt stanice u proizvodnoj staničnoj liniji", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:159:613160

Metadata
TitleStanični ciklus i smrt stanice u proizvodnoj staničnoj liniji
Title (english)Cell cycle and cell death in the production cell line
AuthorAna Ivanić
MentorKristina Radošević (mentor)
Committee memberIgor Slivac (predsjednik povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Cell Technology, Application and Biotransformations)
Zagreb
Defense date and country2020-11-04, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Proizvodne stanične linije važan su ekspresijski sustav za proizvodnju biofarmaceutika koji se primijenjuju u terapiji mnogih oboljenja poput autoimunih bolesti, hematoloških poremećaja, hormonalne neravnoteže, karcinoma, infekcija, genetičkih poremećaja i dr. Kako bi se zadovoljili rastući zahtjevi za biofarmaceuticima te povećala ekonomska isplativost proizvodnje važno je optimirati proces proizvodnje obzirom da se kulturom životinjskih stanica dobivaju niži prinosi proizvoda u odnosu na druge ekspresijske sustave. Neke od strategija koje se primjenjuju u tu svrhu su kontrola staničnog ciklusa, stanične smrti i metabolizma stanica zbog čega je vrlo važno poznavati mehanizme tih staničnih procesa. Navedene strategije pokazale su veliki potencijal primjene u proizvodnji biofarmaceutika. U ovom radu dan je pregled najčešće korištenih proizvodnih staničnih linija, procesa stanične diobe i smrti te kako se kontrolom navedenih staničnih procesa mogu ostvariti poboljšanja u proizvodnji biofarmaceutika.
Abstract (english)
Production cell lines are an importatnt expression system for the production of biopharmaceuticals that are used in the treatment of many diseases such as autoimmune diseases, hematological disorders, hormonal imbalance, cancer, infections, genetic disorders etc. In order to meet growing demands for biopharmaceuticals and increase the economic profitability of production, it is important to optimize the production process, since animal cell cultures result with lower production yields compared to the other expression systems. Some of the strategies applied for this purpose are control of cell cycle, cell death, and cell metabolism, so it is very important to know the mechanisms of these cellular processes. These strategies have shown great potential for application in the production of biopharmaceuticals. This graduation thesis provides an overview of the most commonly used production cell lines, cell division and death and how improvements in the production of biopharmaceuticals can be achieved by controlling these cellular processes.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:613160
Study programmeTitle: Bioprocess Engineering
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka bioprocesnog inženjerstva (magistar/magistra inženjer/inženjerka bioprocesnog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2021-01-13 10:29:48