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master's thesis
Određivanje ostataka makrolidnih antibiotika u uzrocima mišićnog tkiva životinja primjenom LC-MS/MS metode
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. urn:nbn:hr:159:001778
Spahija, Marta
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Antibiotic, Enzyme, Probiotic and Starter Cultures Technology

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Spahija, M. (2020). Određivanje ostataka makrolidnih antibiotika u uzrocima mišićnog tkiva životinja primjenom LC-MS/MS metode (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:001778

Spahija, Marta. "Određivanje ostataka makrolidnih antibiotika u uzrocima mišićnog tkiva životinja primjenom LC-MS/MS metode." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:001778

Spahija, Marta. "Određivanje ostataka makrolidnih antibiotika u uzrocima mišićnog tkiva životinja primjenom LC-MS/MS metode." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:001778

Spahija, M. (2020). 'Određivanje ostataka makrolidnih antibiotika u uzrocima mišićnog tkiva životinja primjenom LC-MS/MS metode', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 14 January 2025, https://urn.nsk.hr/urn:nbn:hr:159:001778

Spahija M. Određivanje ostataka makrolidnih antibiotika u uzrocima mišićnog tkiva životinja primjenom LC-MS/MS metode [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2020 [cited 2025 January 14] Available at: https://urn.nsk.hr/urn:nbn:hr:159:001778

M. Spahija, "Određivanje ostataka makrolidnih antibiotika u uzrocima mišićnog tkiva životinja primjenom LC-MS/MS metode", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:159:001778

Metadata
TitleOdređivanje ostataka makrolidnih antibiotika u uzrocima mišićnog tkiva životinja primjenom LC-MS/MS metode
Title (english)Determination of macrolide antibiotic residues in animal muscle tissue samples using the LC-MS/MS method
AuthorMarta Spahija
MentorBlaženka Kos (mentor)
Committee memberJagoda Šušković (predsjednik povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Antibiotic, Enzyme, Probiotic and Starter Cultures Technology)
Zagreb
Defense date and country2020-12-18, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Makrolidni antibiotici imaju važnu primjenu u stočarstvu i veterinarskoj medicini. Zbog neprikladne upotrebe antibiotika, može doći do pojavljivanja rezistentnih patogenih bakterija u intestinalnom traktu životinja koje se onda mogu prenijeti na ljude putem hrane, kontaminirane vode ili direktnim kontaktom sa životinjama. U ovom radu, ispitana je koncentracija sedamnaest makrolidnih antibiotika u 31 uzoraka mišića različitih životinja, primjenom tekućinske kromatografije visoke djelotvornosti i masene spektrometrije. Od ukupno 21 analiziranog uzorka, samo su dva uzorka bila pozitivna na ostatke ispitivanih makrolidnih antibiotika. Jedan uzorak je bio pozitivan na ostatke antibiotika tildipirozina, dok je drugi bio pozitivan na ostatke antibiotika tilozina A. Detektirane koncentracije rezidua antibiotika u navedenim uzorcima nisu bile veće od najveće dopuštene količine (NDK) propisane uredbom Europske komisije (EC) br. 37/2010.
Abstract (english)
Macrolide antibiotics have important applications in animal husbandry and veterinary medicine. Due to the inappropriate use of antibiotics, resistant pathogenic bacteria can appear in the intestines of animals, which can then be transmitted to humans through food, contaminated water or direct contact with animals. In this experiment, the concentration of seventeen macrolide antibiotics in muscle samples of different animals was examined, using high performance liquid chromatography and mass spectrometry. Out of a total of 21 analyzed samples, only two samples were positive for residues of the tested macrolide antibiotics. One sample was positive for tildipyrosine residues, while the other was positive for tylosin A residues. The detected concentrations of antibiotic residues in these samples did not exceed the maximum residue levels (MRL) prescribed by the European Commission Regulation (EC) no. 37/2010.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:001778
Study programmeTitle: Molecular Biotechnology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka molekularne biotehnologije (magistar/magistra inženjer/inženjerka molekularne biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2021-01-13 11:03:49