prikaz prve stranice dokumenta Genske promjene u tumor supresorskim genima APC i MSH2 kod lobularnih sporadičnih karcinoma dojke
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undergraduate thesis
Genske promjene u tumor supresorskim genima APC i MSH2 kod lobularnih sporadičnih karcinoma dojke
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. urn:nbn:hr:159:687315
Böhm, Tea
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biology and Microbial Genetics

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Böhm, T. (2014). Genske promjene u tumor supresorskim genima APC i MSH2 kod lobularnih sporadičnih karcinoma dojke (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:687315

Böhm, Tea. "Genske promjene u tumor supresorskim genima APC i MSH2 kod lobularnih sporadičnih karcinoma dojke." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. https://urn.nsk.hr/urn:nbn:hr:159:687315

Böhm, Tea. "Genske promjene u tumor supresorskim genima APC i MSH2 kod lobularnih sporadičnih karcinoma dojke." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. https://urn.nsk.hr/urn:nbn:hr:159:687315

Böhm, T. (2014). 'Genske promjene u tumor supresorskim genima APC i MSH2 kod lobularnih sporadičnih karcinoma dojke', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 04 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:687315

Böhm T. Genske promjene u tumor supresorskim genima APC i MSH2 kod lobularnih sporadičnih karcinoma dojke [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2014 [cited 2024 December 04] Available at: https://urn.nsk.hr/urn:nbn:hr:159:687315

T. Böhm, "Genske promjene u tumor supresorskim genima APC i MSH2 kod lobularnih sporadičnih karcinoma dojke", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:159:687315

Metadata
TitleGenske promjene u tumor supresorskim genima APC i MSH2 kod lobularnih sporadičnih karcinoma dojke
Title (english)Genetic changes in APC and MSH2 tumor supressor genes within lobular sporadic breast cancer
AuthorTea Böhm
MentorReno Hrašćan (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Biology and Microbial Genetics)
Zagreb
Defense date and country2014-09-11, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
U ovom radu teoretski je prikazan utjecaj mutacija u tumor supresorskim genima APC i MSH2 na razvoj karcinoma dojke. Proteinski produkti tumor supresorskih gena imaju ulogu kao negativni regulatori staničnog rasta ili apoptoze (programirane stanične smrti), ali također popravljaju oštećenja nastala u DNA molekuli. APC protein ima ključnu ulogu u nekoliko staničnih procesa koji su odlučujući da li će se normalna stanica razviti do tumorske; pomaže i kontrolira koliko često se stanica replicira, kako se veže s drugim stanicama u tkivo, te provjerava da li su se prilikom replikacije stanice kromosomi jednoliko rasporedili. Gen MSH2 smješten na kromosomu 2 kodira za protein Msh2 koji je zaslužan za popravak krivo sparene DNA molekule. MSH2 je tumor supresorski gen čiji se proteinski produkt veže u heterodimer s MSH6 tvoreći MutSα; kompleks koji popravlja krivo sparenu DNA molekulu. Tvori dimer s MSH3 te formira MutSβ kompleks koji također popravlja DNA molekulu.
Abstract (english)
In this work, it has been shown how mutations in APC and MSH2 tumor supressor genes can affect on development of breast cancer (carcinogenesis). Proteins of this genes have role as negative regulators of cell growth or apoptosis (cell death) but also are repairing mismatch DNA. APC has a key role in few cell process which can stop development of normal cell to cancerogenic one. Its protein helps and controls how often cell is replicating, how it binds with other cell in tissue and also controls equal distribution of chromosomes during replication. MSH2 gene located on chromosome 2 has a code for Msh2 protein which controls and repairs mismatch DNA. It forms dimers with MSH3creating MutSα complex.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:687315
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-04-26 13:43:28