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master's thesis
N-ferocenoiliranje C-5 derivata uracila
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. urn:nbn:hr:159:497645
Kuzman, Ivana
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Kuzman, I. (2020). N-ferocenoiliranje C-5 derivata uracila (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:497645

Kuzman, Ivana. "N-ferocenoiliranje C-5 derivata uracila." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:497645

Kuzman, Ivana. "N-ferocenoiliranje C-5 derivata uracila." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:497645

Kuzman, I. (2020). 'N-ferocenoiliranje C-5 derivata uracila', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 22 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:497645

Kuzman I. N-ferocenoiliranje C-5 derivata uracila [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2020 [cited 2024 December 22] Available at: https://urn.nsk.hr/urn:nbn:hr:159:497645

I. Kuzman, "N-ferocenoiliranje C-5 derivata uracila", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:159:497645

Metadata
TitleN-ferocenoiliranje C-5 derivata uracila
Title (english)N-ferrocenoylation of C-5 uracil derivatives
AuthorIvana Kuzman
MentorSenka Djaković (mentor)
Committee memberJasmina Lapić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2020-09-22, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Abstract
Konjugati ferocena i nukleobaza važna su skupina novijih organometalnih spojeva čije komponente posjeduju iznimnu biološku i elektrokemijsku aktivnost. Fizikalno-kemijska svojstva ferocena odgovorna su za njegovu stabilnost u biološkim uvjetima i netoksičnost, stoga su njegovi derivati od sve veće važnosti u medicinskoj kemiji te farmaciji. Ovaj diplomski rad odnosi se na pripravu N-ferocenoiliranja C-5 derivata uracila te regioselektivnost njihovih reakcija. Ferocenoilirajući agens u ovim kopulacijama je ferocenoil-klorid, kao deprotonirajuća baza koristi se natrijev hidrid ili trietilamin, a kao otapalo koristi se DMF ili CH3CN. Kao produkt ovih kopulacija može nastati N1-izomer ili smjesa N1- i N1/N3-izomera, a nijohovo nastajanje uvjetovano je reakcijskim uvjetima.
Abstract (english)
Ferrocene-nucleobase conjugates are an important group of organometallic compounds whose components possess exceptional biological and electrochemical activity. Physicochemical properties of ferrocene are responsabile for its stability in biological medium and non-toxicity, therefore its derivatives play an important role in medicinal chemistry and pharmacy. This graduate thesis refers to the preparation of N-ferrocenoylated C-5 uracil derivatives and the regioselectivity of their reactions. The ferrocenoylating agent in these copulations is ferrocenoyl chloride, sodium hydride or triethylamine is used as a base, and DMF or CH3CN is used as the solvent. Product of these copulations is N1-isomer or a mixture of N1- and N1/N3-isomers, and their formation is tuned by the reaction conditions.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:497645
Study programmeTitle: Food Engineering
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka prehrambenog inženjerstva (magistar/magistra inženjer/inženjerka prehrambenog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2021-01-25 11:05:24