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undergraduate thesis
Učinak kalorijske restrikcije i posta na indukciju autofagije
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. urn:nbn:hr:159:953294
Drenški, Martina
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Toxicology

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Drenški, M. (2021). Učinak kalorijske restrikcije i posta na indukciju autofagije (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:953294

Drenški, Martina. "Učinak kalorijske restrikcije i posta na indukciju autofagije." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:953294

Drenški, Martina. "Učinak kalorijske restrikcije i posta na indukciju autofagije." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:953294

Drenški, M. (2021). 'Učinak kalorijske restrikcije i posta na indukciju autofagije', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 05 August 2024, https://urn.nsk.hr/urn:nbn:hr:159:953294

Drenški M. Učinak kalorijske restrikcije i posta na indukciju autofagije [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2021 [cited 2024 August 05] Available at: https://urn.nsk.hr/urn:nbn:hr:159:953294

M. Drenški, "Učinak kalorijske restrikcije i posta na indukciju autofagije", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:159:953294

Metadata
TitleUčinak kalorijske restrikcije i posta na indukciju autofagije
Title (english)The effect of calorie restriction and fasting on autophagy induction
AuthorMartina Drenški
MentorTeuta Murati (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Toxicology)
Zagreb
Defense date and country2021-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Autofagija je jedan od temeljnih staničnih procesa koji rezultira razgradnjom staničnih komponenti, koje potom služe kao energija i gradivni blokovi za staničnu obnovu. Razlikujemo tri tipa autofagije: makroautofagija, mikroautofagija i autofagija posredovana šaperonom. Iako postoje razlike u načinu odvijanja, sva tri tipa u konačnici dovode do istog ishoda. Istraživanja su ukazala na važnost autofagije u velikom broju stanja, od bakterijskih i virusnih infekcija do karcinoma, neurodegenerativnih, metaboličkih i upalnih bolesti. Autofagija je potaknuta stresnim stanjima, poput oksidacijskog stresa, hipoksije i sl., a stanje nedostatka hranjivih tvari, odnosno kalorijska restrikcija (CR) i post glavni su negenetski pokretači autofagije. I CR i post imaju ulogu u aktiviranju i regulaciji autofagije, što podupiru i rezultati istraživanja koji sugeriraju da je autofagija inducirana u širokom spektru tkiva i organa kao odgovor na uskraćivanje hrane. Dakle, ciljana i precizno kontrolirana aktivacija autofagije predstavlja obećavajuću terapijsku strategiju koja dovodi do poboljšanja zdravlja i normalne funkcije stanica.
Abstract (english)
Autophagy is one of the fundamental cellular processes that results in the deconstruction of cell components which then serve as energy and building blocks for cell renewal. There are three types of autophagy: macroautophagy, microautophagy, and chaperone-mediated autophagy. Although these types of autophagy differ morphologically, all three types lead to the same outcome. Research has pointed out the importance of autophagy in a large number of states, from bacterial and viral infections to cancers, neurodegenerative, metabolic, and inflammatory diseases. Autophagy is stimulated by stress, such as oxidative stress, hypoxia, etc., however, a lack of nutrients, calorie restriction (CR), and fasting are the primary non-genetic stimulants for autophagy. Both CR and fasting play a role in activating and regulating autophagy, which is supported by research suggesting that autophagy is induced in a wide spectrum of tissue and organs as a response to a lack of food. Therefore, a targeted and precisely controlled activation of autophagy presents a promising therapeutic strategy that leads to improved health and the normalization of cell functions.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:953294
Study programmeTitle: Nutrition
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2021-07-28 10:58:33