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undergraduate thesis
Ispitivanje citotoksičnosti prirodnih niskotemperaturnih eutektičkih otapala za farmaceutsku primjenu
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. urn:nbn:hr:159:029137
Šarac, Sunčica
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Cell Technology, Application and Biotransformations

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Šarac, S. (2021). Ispitivanje citotoksičnosti prirodnih niskotemperaturnih eutektičkih otapala za farmaceutsku primjenu (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:029137

Šarac, Sunčica. "Ispitivanje citotoksičnosti prirodnih niskotemperaturnih eutektičkih otapala za farmaceutsku primjenu." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:029137

Šarac, Sunčica. "Ispitivanje citotoksičnosti prirodnih niskotemperaturnih eutektičkih otapala za farmaceutsku primjenu." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:029137

Šarac, S. (2021). 'Ispitivanje citotoksičnosti prirodnih niskotemperaturnih eutektičkih otapala za farmaceutsku primjenu', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:159:029137

Šarac S. Ispitivanje citotoksičnosti prirodnih niskotemperaturnih eutektičkih otapala za farmaceutsku primjenu [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2021 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:159:029137

S. Šarac, "Ispitivanje citotoksičnosti prirodnih niskotemperaturnih eutektičkih otapala za farmaceutsku primjenu", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:159:029137

Metadata
TitleIspitivanje citotoksičnosti prirodnih niskotemperaturnih eutektičkih otapala za farmaceutsku primjenu
Title (english)Evaluation of cytotoxicity of deep eutectic solvents for pharmaceutical application
AuthorSunčica Šarac
MentorManuela Panić (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Cell Technology, Application and Biotransformations)
Zagreb
Defense date and country2021-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Niskotemperaturna eutektička otapala su otapala sastavljena od dvije ili više komponenata od kojih jedna djeluje kao donor, a druga kao akceptor vodikove veze. Povezivanjem se dobije smjesa čija je temperatura tališta znatno niža od one pojedinih komponenata. Niskotemperaturna eutektička otapala smatraju se netoksičnima, ali je prije primjene u industriji potrebno ispitati njihov utjecaj na ljude i okoliš. U ovom radu ispitan je utjecaj triju niskotemperaturnih eutektičkih otapala (timol:kumarin, timol:dekanska kiselina i timol:oktanska kiselina) i terapeutskog eutektičkog otapala (timol:oktanska kiselina:klotrimazol) na HaCaT i HeLa staničnu liniju MTS metodom. Otapala su pokazala nizak inhibitoran učinak na rast stanica te se mogu smatrati nisko citotoksičnim otapalima.
Abstract (english)
Deep eutectic solvents (DESs) are composed of two or more components, one of them being hydrogen bond donor and the other one acceptor. The melting point of the eutectic mixture is significantly lower than that of either of the components. DESs are considered to be non-toxic. However, prior to their large-scale use, it is necessary to determine their impact on human and the environment. In this bachelor thesis, the impact of three DESs (Ty:Cou, Ty:C10, Ty:C8) and one THEDES (Ty:C8:CLO) on HaCaT and HeLa cell line was examined using MTS method. Solvents showed low inhibitory effect on cell growth and can be considered low-cytotoxic.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:029137
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-07-28 11:37:29