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undergraduate thesis
Sinteza i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i fenilalanina
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. urn:nbn:hr:159:195595
Perica, Jana
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Perica, J. (2021). Sinteza i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i fenilalanina (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:195595

Perica, Jana. "Sinteza i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i fenilalanina." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:195595

Perica, Jana. "Sinteza i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i fenilalanina." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:195595

Perica, J. (2021). 'Sinteza i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i fenilalanina', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:195595

Perica J. Sinteza i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i fenilalanina [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2021 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:159:195595

J. Perica, "Sinteza i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i fenilalanina", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:159:195595

Metadata
TitleSinteza i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i fenilalanina
Title (english)Synthesis and spectroscopic analysis of ferrocene dipeptides derived from ferrocene-1,1'-diamine and phenylalanine
AuthorJana Perica
MentorMonika Kovačević (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2021-09-09, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Razmatrajući nedostatke prirodnih peptida koji se mogu prevladati konformacijskim modifikacijama, novija istraživanja se fokusiraju na male molekule koje ugradnjom u peptidne lance induciraju tvorbu različitih okreta i elemenata sekundarne strukture te omogućuju pravilno nabiranje proteinskih lanaca. U sklopu ovog završnog rada pripravit će se i spektroskopski analizirati (IR-, NMR- i CD-spektroskopija) ferocenski dipeptidi Boc-D-Phe-NH-Fn-COOMe (1) i Ac-D-Phe-NH-Fn-COOMe (2) izvedeni iz ferocenske aminokiseline i fenilalanina. Dobiveni dipeptidi su pogodan model za istraživanje i nadogradnju spoznaja o utjecaju strukture i svojstava konstituirajućih aminokiselina na sekundarnu strukturu pripadajućih peptida kao i na njihov potencijalni terapeutski učinak.
Abstract (english)
Considering the limitation of natural peptides that can be overcome by conformational modifications, recent studies explore small molecules that (when incorporated into peptide chains) induce the formation of various turns and elements of secondary structure and allow proper folding of protein chains. As part of this Thesis, ferrocene dipeptides Boc-D-Phe-NH-Fn-COOMe (1) and Ac-D-Phe-NH-Fn-COOMe (2) were synthesized from the ferrocene amino acid and the phenylalanine and spectroscopically analyzed using IR-, NMR- and CD-spectroscopy. The obtained dipeptides are a useful model for new researches and upgrade of knowledge about the influence of amino acid backbones on the secondary structure of peptides as well as their potential therapeutic effect.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:195595
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2021-09-24 09:45:51