prikaz prve stranice dokumenta Priprava i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i valina
  Download
PDF 742.62 KB
undergraduate thesis
Priprava i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i valina
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. urn:nbn:hr:159:157021
Širić, Klara
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Širić, K. (2021). Priprava i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i valina (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:157021

Širić, Klara. "Priprava i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i valina." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:157021

Širić, Klara. "Priprava i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i valina." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:157021

Širić, K. (2021). 'Priprava i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i valina', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 21 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:157021

Širić K. Priprava i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i valina [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2021 [cited 2024 December 21] Available at: https://urn.nsk.hr/urn:nbn:hr:159:157021

K. Širić, "Priprava i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i valina", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:159:157021

Metadata
TitlePriprava i spektroskopska analiza ferocenskih dipeptida izvedenih iz ferocen-1,1'-diamina i valina
Title (english)Preparation and spectroscopic analysis of ferrocene dipeptides derived from ferrocene-1,1'-diamine and valine
AuthorKlara Širić
MentorMonika Kovačević (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2021-09-09, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Sekundarna struktura proteina ima bitnu ulogu u konačnoj strukturi proteina, stabilnosti, presavijanju, biološkim procesima i u samoj funkciji proteina, te se stoga pokušava predvidjeti i usmjeriti, kako bi proteini postali konformacijski fleksibilniji, stabilniji i time terapeutski primjenjiviji. U ovom je radu opisana sinteza i konformacijska analiza biokonjugata Boc-D-Val-NH-Fn- COOMe (1) i Ac-D-Val-NH-Fn-COOMe (2) (Ac = acetil, Boc = tert-butoksikarbonil) koji su pripravljeni iz voluminozne aminokiseline valina i ferocenske aminokiseline. S ciljem utvrđivanja mogućeg steričkog utjecaja valinskog bočnog ogranaka na uspostavu sekundarne strukture rezultirajućih peptida, provedena je konformacijska analiza (IR-, NMR- i CD-spektroskopija).
Abstract (english)
The secondary structure of a protein plays an important role in the final structure of the protein, stability, folding, biological processes and in the function of the protein itself. Therefore, scientific researches are made to predict and direct proteins to be more conformationally flexible, stable and therapeutically applicable. This paper describes the synthesis and conformational analysis of the bioconjugates Boc-D-Val-NH-Fn-COOMe (1) and Ac-D-Val-NH-Fn-COOMe (2) (Ac = acetyl, Boc = tert-butoxycarbonyl) which are prepared from the voluminous amino acid valine and the ferrocene amino acid. In order to determine the possible steric influence of the valine backbone on the formation of the secondary structure of the resulting peptides, conformational analysis (IR, NMR and CD spectroscopy) was performed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:157021
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2021-09-24 09:59:46