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undergraduate thesis
Peptidomimetici
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. urn:nbn:hr:159:432448
Širac, Tea
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Širac, T. (2014). Peptidomimetici (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:432448

Širac, Tea. "Peptidomimetici." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. https://urn.nsk.hr/urn:nbn:hr:159:432448

Širac, Tea. "Peptidomimetici." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. https://urn.nsk.hr/urn:nbn:hr:159:432448

Širac, T. (2014). 'Peptidomimetici', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 02 June 2024, https://urn.nsk.hr/urn:nbn:hr:159:432448

Širac T. Peptidomimetici [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2014 [cited 2024 June 02] Available at: https://urn.nsk.hr/urn:nbn:hr:159:432448

T. Širac, "Peptidomimetici", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:159:432448

Metadata
TitlePeptidomimetici
Title (english)Peptidomimetics
AuthorTea Širac
MentorLidija Barišić (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2014-09-11, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Podložnost proteolitičkim enzimima, polarnost koja otežava transport kroz lipidni dvosloj te prevelika konformacijska sloboda ograničavaju terapeutsku primjenu peptida. Primjenom njihovih mimetika moguće je prevladati spomenute nedostatke, tako da dizajn i sinteza peptidomimetika predstavljaju moćno oruđe za pripravu lijekova koji djeluju kao inhibitori enzima ili ligandi za različite receptore. Dizajn peptidomimetika bazira se na: (i) zamjeni dijela peptidne okosnice nepeptidnim fragmentom, (ii) modifikaciji bočnih ogranaka i(li) (iii) ograničavanju konformacijske slobode, s ciljem oponašanja onog fragmenta peptidne sekundarne strukture koji je odgovoran za molekulsko prepoznavanje. Na taj se način oponaša biološka aktivnost prirodnih peptida, a moguće je ostvariti i poboljšanu selektivnost, efikasnost, biodostupnost i produljenu biološku aktivnost.
Abstract (english)
The low metabolic stability towards proteolytic enzymes, polar character that disables their transport through lipide bilayer as well as the conformational freedom limit their therapeutic application. Since those adversities might be prevailed by using of their mimetics, peptidomimetic design and synthesis present a powerfull tools for the preparation of drugs acting as enzyme inhibitors or receptor ligands. The design of peptidomimetics is based on: (i) the replacement of the peptide backbone with non-peptide fragment, (ii) the modification of the side-chains and/or (iii) the locking the conformational freedom in order to mimic secondary structure element responsible for molecular recognition. This approach not only enables the mimicking of the biological activity, but also improve selectivity, efficiency, bioavailability and activity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:432448
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-04-27 08:16:27