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undergraduate thesis
Procjena toksičnosti niskotemperaturnih eutektičkih otapala za razvoj formulacije ciprofloksacina
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. urn:nbn:hr:159:541455
Brdarević, Katarina
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Brdarević, K. (2021). Procjena toksičnosti niskotemperaturnih eutektičkih otapala za razvoj formulacije ciprofloksacina (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:541455

Brdarević, Katarina. "Procjena toksičnosti niskotemperaturnih eutektičkih otapala za razvoj formulacije ciprofloksacina." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:541455

Brdarević, Katarina. "Procjena toksičnosti niskotemperaturnih eutektičkih otapala za razvoj formulacije ciprofloksacina." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:541455

Brdarević, K. (2021). 'Procjena toksičnosti niskotemperaturnih eutektičkih otapala za razvoj formulacije ciprofloksacina', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 25 August 2024, https://urn.nsk.hr/urn:nbn:hr:159:541455

Brdarević K. Procjena toksičnosti niskotemperaturnih eutektičkih otapala za razvoj formulacije ciprofloksacina [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2021 [cited 2024 August 25] Available at: https://urn.nsk.hr/urn:nbn:hr:159:541455

K. Brdarević, "Procjena toksičnosti niskotemperaturnih eutektičkih otapala za razvoj formulacije ciprofloksacina", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:159:541455

Metadata
TitleProcjena toksičnosti niskotemperaturnih eutektičkih otapala za razvoj formulacije ciprofloksacina
Title (english)Assessment of toxicity deep eutectic solvents for formulation development of ciprofloxacin
AuthorKatarina Brdarević
MentorManuela Panić (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
Zagreb
Defense date and country2021-09-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Eutektička otapala zelena su otapala sastavljena od donora i akceptora vodikove veze koja u određenom molarnom omjeru imaju temperaturu tališta nižu od pojedinačnih komponenti pa su najčešće pri sobnoj temperaturi u tekućem agregacijskom stanju. Komponente od kojih se pripremaju eutektička otapala nisu toksične, no potrebno je ispitati njihov sinergijski učinak kako bi se procijenio njihov utjecaj na ljude i okoliš. U ovom radu ispitana je citotoksičnost triju različitih eutektičkih otapala (limunska kiselina: glukoza, betain: jabučna kiselina: glukoza, glicerol: glukoza) kao i terapeutskog eutektičkog otapala (limunska kiselina: glukoza: ciprofloksacin) na Caco-2 i HeLa staničnu liniju MTS metodom. Otapala nisu pokazala inhibitoran učinak na rast stanica pa se mogu smatrati netoksičnim otapalima.
Abstract (english)
Deep eutectic solvents are green solvents, formed by a donor and an acceptor of hydrogen bond. At room temperatures they are usually liquids, due to the fact that in certain molar ratios their melting point is lower than a melting points of each forming compound. DESs forming compounds are considered to be non-toxic, but before their application it is necessary to determine synergic effect of forming compounds and to assess their impact on human and the environment. In this thesis, the impact of three DESs (citric acid:glucose, betaine:malic acid:glucose, glycerol:glucose) and one THEDES (citric acid: glucose: ciprofloxacin) on Caco-2 and HeLa cell line was examined using MTS method. Solvents did not show inhibitory effect on cell growth and can be considered noncytotoxic.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:541455
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-09-29 11:58:24