prikaz prve stranice dokumenta Ispitivanje učinka biološki aktivnih tvari iz kore cikle i kore banane na stanične linije i makromolekule
  Download
PDF 2.63 MB
master's thesis
Ispitivanje učinka biološki aktivnih tvari iz kore cikle i kore banane na stanične linije i makromolekule
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. urn:nbn:hr:159:116706
Komljenović, Anamaria
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biology and Microbial Genetics

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Komljenović, A. (2021). Ispitivanje učinka biološki aktivnih tvari iz kore cikle i kore banane na stanične linije i makromolekule (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:116706

Komljenović, Anamaria. "Ispitivanje učinka biološki aktivnih tvari iz kore cikle i kore banane na stanične linije i makromolekule." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:116706

Komljenović, Anamaria. "Ispitivanje učinka biološki aktivnih tvari iz kore cikle i kore banane na stanične linije i makromolekule." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:116706

Komljenović, A. (2021). 'Ispitivanje učinka biološki aktivnih tvari iz kore cikle i kore banane na stanične linije i makromolekule', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 04 August 2024, https://urn.nsk.hr/urn:nbn:hr:159:116706

Komljenović A. Ispitivanje učinka biološki aktivnih tvari iz kore cikle i kore banane na stanične linije i makromolekule [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2021 [cited 2024 August 04] Available at: https://urn.nsk.hr/urn:nbn:hr:159:116706

A. Komljenović, "Ispitivanje učinka biološki aktivnih tvari iz kore cikle i kore banane na stanične linije i makromolekule", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:159:116706

Metadata
TitleIspitivanje učinka biološki aktivnih tvari iz kore cikle i kore banane na stanične linije i makromolekule
Title (english)Effects of biologically active compounds from banana peel and red beetroot peel on cell lines and macromolecules
AuthorAnamaria Komljenović
MentorKsenija Durgo (mentor)
Committee memberVišnja Gaurina-Srček (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Biology and Microbial Genetics)
Zagreb
Defense date and country2021-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Interdisciplinary Technical Sciences
Abstract
Prilikom prerade cikle i banane proizvodi se velika količina otpada koja se može iskoristiti u različite svrhe. Kora cikle i banane kao nusproizvod sadržava fitokemikalije koje imaju izraženo antioksidacijsko djelovanje koje ima ulogu u zaštiti od različitih kroničnih i kardiovaskularnih bolesti. Cilj rada je istražiti biološki učinak ekstrakta kore cikle i kore banane na stanične makromolekule te humane stanične linije karcinoma debelog crijeva (Caco-2), karcinoma usne šupljine (Cal27) i hepatocelularnog karcinoma jetre Hep G2 u koncentracijama za koje je realno očekivati da budu unesene u organizam tijekom 24 sata. Rezultati su pokazali da fitokemikalije iz kore cikle i kore banane djeluju protektivno na lipide, da izazivaju genotoksični učinak samo na staničnoj liniji jetre te da pri višim koncentracijama induciraju glutation. Istraživani uzorci nisu pokazali značajno antioksidativno djelovanje na modelnim molekulama DNA i proteina dok u određenim uvjetima imaju i prooksidativno djelovanje.
Abstract (english)
A large amount of waste is produced when red beetroot and bananas are processed. Their by-products can be used for various purposes and they contain phytochemicals that have antioxidative effect that has a role in protection of various chronic and cardiovasular diseases. The aim of this study is to determine biological effect of beetroot peel and banana peel extracts on cellular macromolecules, human colon cancer cell line Caco-2, human oral carcinoma cell line Cal27 and hepatocellular liver carcinoma cell line Hep G2 in concentrations that are expected to be consumed over a 24 hour period. The results showed that phytochemicals contained in the beetroot peel and banana peel have a protective effect on lipids while they do have genotoxic effect only on HepG2 cell line and they induce glutathione at higher concentrations. Used extracts did not show a significant antioxidative effect on DNA model and protein molecules, while under certain conditions they also have a prooxidative effect.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:116706
Study programmeTitle: Food Safety Management
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka upravljanja sigurnošću hrane (magistar/magistra inženjer/inženjerka upravljanja sigurnošću hrane)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2021-10-11 12:45:07