prikaz prve stranice dokumenta Potencijalno bioaktivno djelovanje ksantohumola – preniliranog flavonoida hmelja (Humulus lupulus L.)
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master's thesis
Potencijalno bioaktivno djelovanje ksantohumola – preniliranog flavonoida hmelja (Humulus lupulus L.)
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. urn:nbn:hr:159:138166
Mišković, Paula
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Toxicology

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Mišković, P. (2022). Potencijalno bioaktivno djelovanje ksantohumola – preniliranog flavonoida hmelja (Humulus lupulus L.) (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:138166

Mišković, Paula. "Potencijalno bioaktivno djelovanje ksantohumola – preniliranog flavonoida hmelja (Humulus lupulus L.)." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:138166

Mišković, Paula. "Potencijalno bioaktivno djelovanje ksantohumola – preniliranog flavonoida hmelja (Humulus lupulus L.)." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:138166

Mišković, P. (2022). 'Potencijalno bioaktivno djelovanje ksantohumola – preniliranog flavonoida hmelja (Humulus lupulus L.)', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 19 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:138166

Mišković P. Potencijalno bioaktivno djelovanje ksantohumola – preniliranog flavonoida hmelja (Humulus lupulus L.) [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2022 [cited 2024 December 19] Available at: https://urn.nsk.hr/urn:nbn:hr:159:138166

P. Mišković, "Potencijalno bioaktivno djelovanje ksantohumola – preniliranog flavonoida hmelja (Humulus lupulus L.)", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:159:138166

Metadata
TitlePotencijalno bioaktivno djelovanje ksantohumola – preniliranog flavonoida hmelja (Humulus lupulus L.)
Title (english)Potential bioactive effect of xanthohumol prenylated flavonoid from hops (Humulus lupulus L.)
AuthorPaula Mišković
MentorTeuta Murati (mentor)
Committee memberIvana Kmetič (predsjednik povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Toxicology)
Zagreb
Defense date and country2022-04-01, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Biljka Humulus lupulus L., odnosno njene šišarice, izlučuju lupulin, cvjetni prah bogat različitim bioaktivnim kemijskim spojevima te karakterističnom skupinom spojeva, preniliranim flavonoidima. Najvažniji i najzastupljeniji prenilirani halkon je bioaktivni spoj ksantohumol (KSN). U ovom radu dan je pregled mehanizama djelovanja KSN-a koja uključuju imunomodulatorno, antiproliferativno, citotoksično, antiangiogeno, antioksidacijsko, antigenotoksično, antimikrobno i antiviralno djelovanje. KSN uspješno inhibira rast tumora i angiogenezu te inducira apoptozu tumorskih stanica u in vitro i in vivo modelima. Bioaktivnost KSN-a i snažno antitumorsko djelovanje ukazuju na mogući terapijski potencijal ovog spoja te potrebu za daljnjim istraživanjima.
Abstract (english)
The hop cones of the plant Humulus lupulus L. secrete lupulin, a resinous powder rich in various bioactive compounds with characteristic group of compounds, prenylflavonoids. The most important prenylated chalcone is bioactive compound xanthohumol (XN). This review shows mechanisms of actions of XN including immunomodulatory, antiproliferative, cytotoxic, antiangiogenic, antioxidant, antigenotoxic, antimicrobial and antiviral activity. XN successfully inhibits tumor growth and angiogenesis and induces tumor cell apoptosis in in vitro and in vivo models. Bioactivity and strong antitumor activity of XN indicate a possible therapeutic potential of this compound and the need for further studies.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:138166
Study programmeTitle: Food Engineering
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka prehrambenog inženjerstva (magistar/magistra inženjer/inženjerka prehrambenog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2022-05-27 10:10:15