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master's thesis
Računalna analiza modela metabolizma masti
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. urn:nbn:hr:159:240808
Kosić, Martina
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Process Engineering
Laboratory for Measurement, Regulation and Automatisation

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Kosić, M. (2022). Računalna analiza modela metabolizma masti (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:240808

Kosić, Martina. "Računalna analiza modela metabolizma masti." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:240808

Kosić, Martina. "Računalna analiza modela metabolizma masti." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:240808

Kosić, M. (2022). 'Računalna analiza modela metabolizma masti', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 03 September 2024, https://urn.nsk.hr/urn:nbn:hr:159:240808

Kosić M. Računalna analiza modela metabolizma masti [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2022 [cited 2024 September 03] Available at: https://urn.nsk.hr/urn:nbn:hr:159:240808

M. Kosić, "Računalna analiza modela metabolizma masti", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:159:240808

Metadata
TitleRačunalna analiza modela metabolizma masti
Title (english)Computional analysis of fat metabolism model
AuthorMartina Kosić
MentorAna Jurinjak Tušek (mentor)
Committee memberJasenka Gajdoš Kljusurić (predsjednik povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Process Engineering)
(Laboratory for Measurement, Regulation and Automatisation)
Zagreb
Defense date and country2022-04-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
U ovom radu provedena je računalna analiza modela metabolizma masti primjenom programskog paketa CellDesigner i WR Mathematica. Provedene su simulacije modela primjenom različitih početnih koncentracija glukoze i triaciglicerola u krvnoj plazmi pri različitim obrocima (zajutrak, ručak, međuobrok i večera). Metodama lokalne i globalne parametarske osjetljivosti analizirani su najosjetljiviji metaboliti modela. Rezultati simulacija ukazuju na važnost hormona inzulin, ne samo za metabolizam i dostupnost ugljikohidrata u organizmu, nego i za sam metabolizam masti koji se najbolje primjećuje na primjeru dinamike promjene koncentracije neesterificiranih masnih kiselina. Analiza lokalne i globalne parametarske osjetljivosti pokazala je da najveću osjetljivost na promjenu parametara modela ima koncentracija egzogeni triacilglicerola.
Abstract (english)
A computer analysis of the fat metabolism model was performed using the CellDesigner and WR Mathematica software packages. Simulations of the model were performed using different initial blood plasma glucose and triaciglycerol plasma concentration at different meals (breakfast, lunch, snack and dinner). The most sensitive metabolites of the model were analyzed by local and global parametric sensitivity methods. The results of the simulations indicate the importance of the hormone insulin, not only for the metabolism and availability of carbohydrates in the body, but also for the fat metabolism itself, which is best seen in the dynamics of changes in the concentration of non-esterified fatty acids. Analysis of local and global parametric sensitivity showed that the concentration of exogenous triacylglycerol has the greatest sensitivity to changes in model parameters.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:240808
Study programmeTitle: Nutrition
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2022-06-29 10:11:30